Results 171 to 180 of about 765,441 (312)

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

An optimized protocol for metabolic measurement in 3D tumor spheroids derived from primary and established glioblastoma cells. [PDF]

PLoS One
Al-Robaiy S, Hohmann U, Simm A, Dehghani F, Prell J, Strauss C, Hohmann T.   +6 more
europepmc   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Evaluating Spatial Normalization Methods for the Human Brain

, 2005
Cortical stimulation mapping (CSM) studies have shown cortical locations for language function are highly variable from one subject to the next. Because no two cortical surfaces are alike and language is a higher order cognitive function, observed ...
Smith, Veronica S
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Achieving Effective Batch-to-Batch Error Correction through Suppression Correction and Dual MSTUS Normalization. [PDF]

Anal Chem
Ghosh D, Kar J, de Jong FA, Beecher C, Shulaev V.   +4 more
europepmc   +1 more source

Normalization and Gene p-Value Estimation: Issues in Microarray Data Processing

, 2008
Introduction: Numerous methods exist for basic processing, e.g. normalization, of microarray gene expression data. These methods have an important effect on the final analysis outcome.
Ralf Zimmer, Robert Küffner, Katrin Fundel, Thomas Aigner   +3 more
core  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

RF-SVR-based prediction methodology for metal tube-bending rebound: Handling non-uniformity and limited sample challenges. [PDF]

PLoS One
Fang Z, Zhang P, Li L, Zhang Q.
europepmc   +1 more source

On the normalization of a priority vector associated with a reciprocal relation. [PDF]

In this paper we show that the widely used normalization constraint SUM(i=1,n) wi = 1 does not apply to the priority vectors associated with reciprocal relations, whenever additive transitivity is involved.
Matteo Brunelli, Michele Fedrizzi
core