Results 101 to 110 of about 994,574 (330)

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

Molecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh, Nikola Tom, Anna Schrøder Lassen, Helene Brasch Lind Petersen, Ulrik Kristoffer Stoltze, Karin Wadt, Kjeld Schmiegelow, Matteo Tiberti, Elena Papaleo   +8 more
wiley   +1 more source

A METHOD FOR THE SOLUTION OF NORMAL EQUATIONS

The Journal of Agriculture of the University of Puerto Rico, 1944
A new method of solving normal equations is presented. A comparison is made of the application of the method to a multiple regression case used by Dwyer to illustrate his abbreviation of the Doolittle method. The proposed method for relatively, small numbers of unknowns at least, is simpler than Dwyer's method, considered to date to be one, if not the ...
openaire   +2 more sources

Sur la solution d'équations normales [PDF]

Astronomische Nachrichten, 1893
n ...
openaire   +2 more sources

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Normalized solutions for the Kirchhoff equation with combined nonlinearities in ℝ4

Advances in Nonlinear Analysis
In this article, we study the following Kirchhoff equation with combined nonlinearities: −a+b∫R4∣∇u∣2dxΔu+λu=μ∣u∣q−2u+∣u∣2u,inR4,∫R4∣u∣2dx=c2,\left\{\begin{array}{l}-\left(a+b\mathop{\displaystyle \int }\limits_{{{\mathbb{R}}}^{4}}{| \nabla u| }^{2}{\rm ...
Qiu Xin, Ou Zeng-Qi, Tang Chun-Lei, Lv Ying   +3 more
doaj   +1 more source

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

Solutions with prescribed mass for the Sobolev critical Schrödinger–Poisson system with p-Laplacian

Bulletin of Mathematical Sciences
In this paper, we are concerned with the existence and properties of ground states for the quasilinear Schrödinger–Poisson system with combined critical nonlinearities −Δpu+γϕ|u|p−2u=λ|u|p−2u+μ|u|q−2u+|u|p∗−2uin ℝ3,−Δϕ=|u|pin ℝ3, having prescribed mass ...
Kai Liu, Xiaoming He
doaj   +1 more source

Beam-size-related phenomena and effective normalization in energy-dispersive EXAFS for the study of heterogeneous catalysts, powder materials and the processes they mediate: observations and (some) solutions [PDF]

, 2007
Mark A. Newton
openalex   +1 more source

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source

Multiplicity of normalized solutions for nonlinear Choquard equations

Advanced Nonlinear Studies
In this paper, we consider the following nonlinear Choquard equation with prescribed L 2-norm: −Δu+λu=Iα∗F(u)f(u) in RN,∫RN|u|2dx=a>0,u∈H1(RN), $\begin{cases}-{\Delta}u+\lambda u=\left({I}_{\alpha }\ast F\left(u\right)\right)f\left(u\right) \,\text{in}\,
Long Chun-Fei, Deng Chonghao, Li Gui-Dong, Tang Chun-Lei   +3 more
doaj   +1 more source