Results 101 to 110 of about 299,484 (312)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Normalized solutions for the Choquard equations with critical nonlinearities

Advances in Nonlinear Analysis
This study is concerned with the existence of normalized solutions for the Choquard equations with critical nonlinearities −Δu+λu=f(u)+(Iα∗∣u∣2α*)∣u∣2α*−2u,inRN,∫RN∣u∣2dx=a2,\left\{\begin{array}{l}-\Delta u+\lambda u=f\left(u)+\left({I}_{\alpha }\ast ...
Gao Qian, He Xiaoming
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Existence of normalized solutions to Kirchhoff-Boussinesq equations in the subcritical and supercritical regime

Electronic Journal of Differential Equations
In this article we study the existence of normalized solutions to the Kirchhoff-Boussinesq equation under the mass constraint $\|u\|_{2}=c$. In the $L^{2}$-subcritical regime, we apply Ekeland's variational principle and concentration compactness method ...
Chunling Tao, Lintao Liu, Kaimin Teng
doaj  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Normalized solutions for an horizontal transmission problem

, 2020
Giovany M. Figueiredo, Gaetano Siciliano
openalex   +1 more source

Solution of rank deficient normals

, 1981
Technical note written as input to the early studies of the ESA space astrometry project Hipparcos.
openaire   +1 more source

Multiplicity of normalized solutions for nonlinear Choquard equations

Advanced Nonlinear Studies
In this paper, we consider the following nonlinear Choquard equation with prescribed L 2-norm: −Δu+λu=Iα∗F(u)f(u) in RN,∫RN|u|2dx=a>0,u∈H1(RN), $\begin{cases}-{\Delta}u+\lambda u=\left({I}_{\alpha }\ast F\left(u\right)\right)f\left(u\right) \,\text{in}\,
Long Chun-Fei, Deng Chonghao, Li Gui-Dong, Tang Chun-Lei   +3 more
doaj   +1 more source

Positive Normalized Solutions to a Kind of Fractional Kirchhoff Equation with Critical Growth

Fractal and Fractional
In this paper, we have investigated the existence of normalized solutions for a class of fractional Kirchhoff equations involving nonlinearity and critical nonlinearity. The nonlinearity satisfies L2-supercritical conditions.
Shiyong Zhang, Qiongfen Zhang
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source