Results 101 to 110 of about 490,657 (289)
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Discovery of a 459 Hz Burst Oscillation in XTE J1810−189 with NICER
The Astrophysical JournalWe present a detailed temporal study of a type I X-ray burst from the neutron star low-mass X-ray binary (NS-LMXB) XTE J1810−189, observed on 2023 April 27 using the Neutron Star Interior Composition Explorer.
M. Varun +3 more
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Joint Learning of NNeXtVLAD, CNN and Context Gating for Micro-Video Venue Classification
IEEE Access, 2019 Currently, micro-videos have grown explosively on various online social platforms. Accordingly, how to encode them to yield effective representation attracts our attention. NeXtVLAD is such an effective network that aggregates frame-level features into a
Wei Liu +5 more
doaj +1 more source
NKCC1: A key regulator of glioblastoma progression
Molecular Oncology, EarlyView.Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen +5 more
wiley +1 more source
A new robotic horseback-riding simulator for riding lessons and equine-assisted therapy
International Journal of Advanced Robotic Systems, 2018 Robotic horseback-riding simulators have been successfully used as a substitute for real horses in areas of therapy, riding lessons, fitness, and entertainment, and several have been developed.
Wonsik Lee +3 more
doaj +1 more source
Normal probability plots and the estimation of distribution tails
Economics Letters, 1982 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
University of Florida, Gainesville, FL 32611, USA ( host institution ) +3 more
openaire +2 more sources
FEBS Open Bio, EarlyView.We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima +4 more
wiley +1 more source
Nonparametric Density Estimation for Linear Processes with Infinite Variance [PDF]
We consider nonparametric estimation of marginal density functions of linear processes by using kernel density estimators. We assume that the innovation processes are i.i.d. and have infinite-variance.
Honda, Toshio
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