Results 81 to 90 of about 229,506 (303)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
, 2022 Energy is deposited into experiment packages due to post-shutdown decay heat created from delayed particles. Modeling these delayed particles in a reactor assists researchers in quantifying the expected energy deposition sources to an experiment package ...
Boland, Eli James
core
Normalized random measures driven by increasing additive processes [PDF]
, 2004 This paper introduces and studies a new class of nonparametric prior distributions. Random probability distribution functions are constructed via normalization of random measures driven by increasing additive processes.
PRUENSTER, IGOR +4 more
core +1 more source
Normal probability plots and the estimation of distribution tails
Economics Letters, 1982 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
University of Florida, Gainesville, FL 32611, USA ( host institution ) +3 more
openaire +2 more sources
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Tail Asymptotics for the Bivariate Skew Normal in the General Case
Journal of Statistical Theory and PracticeAbstract The present paper is a sequel to and generalization of [10] whose main result gives the asymptotic behaviour as $$ u \rightarrow 0^{+}$$ u
Thomas Fung, Eugene Seneta
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
, 2021 A–Cross-sections taken at the base of the dorsal fin. B—Cross-sections taken at the base of the tail fluke. C—Cross-sections taken at the top of the dorsal fin. D—Cross-sections taken at the top of the tail fluke.
Ursula Siebert (79250) +5 more
core +1 more source
Distributional Properties of means of Random Probability Measures [PDF]
The present paper provides a review of the results concerning distributional properties of means of random probability measures. Our interest in this topic has originated from inferential problems in Bayesian Nonparametrics.
Antonio Lijoi, Igor Pruenster
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