Results 101 to 110 of about 229,506 (303)

A large deviation principle for the normalized excursion of $α$-stable Lévy processes without negative jumps

We establish a large deviation principle for the normalized excursion and bridge of an $α$-stable Lévy process without negative jumps, with ...
Miermont, Grégory, Dort, Léo, Goldschmidt, Christina   +2 more
core   +1 more source

Repurpose the antimicrobial peptide Buforin II for plasmid transformation into Escherichia coli

CTU Journal of Innovation and Sustainable Development
Antimicrobial peptides Buforin II, derived from histone H2A, demonstrates strong cell-penetrating activity without cell lysis and strong affinity for internal cellular nucleic acids, making it a potential candidate for macromolecule delivery into ...
Thanh Ngoc Nguyen, Le Minh Bui
doaj   +3 more sources

Evaluating statistical downscaling and bias-correction methods for climate extremes across major Chinese River basins

Ain Shams Engineering Journal
Statistical downscaling and bias correction (SDBC) translate coarse-resolution global climate model (GCM) output into regional information, yet skill for extremes is strongly regime-dependent.
Le Xinlong, Kang Ling, Wu Xilong, Zhou Liwei   +3 more
doaj   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Characterization of N_TAIL in the context of intact nucleocapsids.

, 2013
(A) Superposition of the 1H-15N HSQC spectra of isolated NTAIL (red) and intact nucleocapsids (blue). The spectra were obtained at a 1H frequency of 600 MHz and 293 K.
Malene Ringkjøbing Jensen (204257), Johnny Habchi (245452), Filip Yabukarski (204249), David Blocquel (463521), Marc Jamin (204265), Martin Blackledge (204261), Nicolas Papageorgiou (219767), Rob W. H. Ruigrok (146190), Sonia Longhi (24876), Guillaume Communie (463520), Robert Schneider (235654), Nicolas Tarbouriech (204251)   +11 more
core   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

On Robust Tail Index Estimation and Related Topics

, 2013
In this work we discuss tail index estimation for heavy-tailed distributions with an emphasis on robustness. After a short introduction we provide a theoretical background treating regular variation and its extensions.
Schell, Dieter
core  

Discovery of a 459 Hz Burst Oscillation in XTE J1810−189 with NICER

The Astrophysical Journal
We present a detailed temporal study of a type I X-ray burst from the neutron star low-mass X-ray binary (NS-LMXB) XTE J1810−189, observed on 2023 April 27 using the Neutron Star Interior Composition Explorer.
M. Varun, Neal Titus Thomas, S. B. Gudennavar, S. G. Bubbly   +3 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source