Results 41 to 50 of about 229,506 (303)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Tail dependence between order statistics

, 2012
In this work, we introduce the s, k-extremal coefficients for studying the tail dependence between the s-th lower and k-th upper order statistics of a normalized random vector. If its margins have tail dependence then so do their order statistics, with
Ferreira, Marta, Ferreira, Marta Susana, Marta Ferreira, Helena Ferreira, Ferreira, Helena   +4 more
core   +1 more source

Logit Normalization for Long-Tail Object Detection

International Journal of Computer Vision
Real-world data exhibiting skewed distributions pose a serious challenge to existing object detectors. Moreover, the samplers in detectors lead to shifted training label distributions, while the tremendous proportion of background to foreground samples severely harms foreground classification.
Liang Zhao 0019, Yao Teng, Limin Wang 0002   +2 more
openaire   +2 more sources

Cauchy, normal and correlations versus heavy tails

Statistics & Probability Letters, 2022
A surprising result of Pillai and Meng (2016) showed that a transformation $\sum_{j=1}^n w_j X_j/Y_j$ of two iid centered normal random vectors, $(X_1,\ldots, X_n)$ and $(Y_1,\ldots, Y_n)$, $n>1$, for any weights $0\leq w_j\leq 1$, $ j=1,\ldots, n$, $\sum_{j=1}^n w_j=1$, has a Cauchy distribution regardless of any correlations within the normal ...
Xu, Hui, Cohen, Joel E., Davis, Richard A., Samorodnitsky, Gennady   +3 more
openaire   +3 more sources

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Non-uniform bounds and edgeworth expansions in self-normalized limit theorems

, 2022
This thesis is devoted to the study of Edgeworth expansions in limit theorems for self-normalized sums. We establish non-uniform bounds for expansions in the central limit theorem while only imposing minimal moment conditions.
Beckedorf, Pascal
core   +1 more source

The First Prosthetic Alligator Tail and the Role of the Tail in Normal Terrestrial Locomotion

The FASEB Journal, 2015
An American alligator (Alligator mississippiensis) after losing all but the most proximal tail exhibits abnormal walking.
Justin Georgi, Marc Jacofsky, Kevin Manfredi   +2 more
openaire   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Upper Tail Large Deviations in First Passage Percolation

, 2021
For first passage percolation on ℤ2 with i.i.d. bounded edge weights, we consider the upper tail large deviation event, i.e., the rare situation where the first passage time between two points at distance n is macroscopically larger than typical ...
Basu, Riddhipratim, Riddhipratim Basu, Shirshendu Ganguly, Allan Sly, Sly, Allan, Ganguly, Shirshendu   +5 more
core   +1 more source