Results 51 to 60 of about 493,232 (287)

"Nonlinear" covariance matrix and portfolio theory for non-Gaussian multivariate distributions

, 1999
This paper offers a precise analytical characterization of the distribution of returns for a portfolio constituted of assets whose returns are described by an arbitrary joint multivariate distribution.
Andersen, J. V., Simonetti, P., Sornette, D.   +2 more
core   +1 more source

Head-Tail Modes for Strong Space Charge [PDF]

, 2008
The head-tail modes are described for the space charge tune shift significantly exceeding the synchrotron tune. A general equation for the modes is derived. The spatial shapes of the modes, their frequencies, and coherent growth rates are explored.
A. Burov, A. Chao
core   +3 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

The effects of methylated flavonoids on depression-like activity and pro-inflammatory cytokine thresholds in mice induced by repeated finasteride administration

European Journal of Inflammation, 2021
The aim of the study was to investigate the influence of naringenin (NGN) and its methylated derivatives (50 or 100 mg kg−1) on finasteride-caused depression-like performance in mice to identify the effects on behavior and biomarkers of inflammation in ...
Bin She, Huajin Wu, Qin Xie, Mingjuan Zhang, Nan Zhou, Deyu Pei, Zheming Tu   +6 more
doaj   +1 more source

Logit Normalization for Long-Tail Object Detection

International Journal of Computer Vision
Real-world data exhibiting skewed distributions pose a serious challenge to existing object detectors. Moreover, the samplers in detectors lead to shifted training label distributions, while the tremendous proportion of background to foreground samples severely harms foreground classification.
Liang Zhao, Yao Teng, Limin Wang
openaire   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Protective Effect of Tiger Nut (Cyperus Esculentus) Against Monosodium Glutamate-Induced Reproductive Dysfunction in Male Wistar Rats

Veterinary Sciences and Practices
Monosodium glutamate (MSG) is a widespread flavour enhancer linked to health risks, including male reproductive dysfunction. This study investigated tiger nut (Cyperus esculentus) as a potential protective agent against MSG-induced reproductive issues in
Abraham Akinyemi, Olumide Ajani, Olumide Akinniyi   +2 more
doaj   +1 more source

Extreme deviations and applications

, 1997
Stretched exponential probability density functions (pdf), having the form of the exponential of minus a fractional power of the argument, are commonly found in turbulence and other areas.
Frisch, U., Sornette, D.
core   +3 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source