Results 51 to 60 of about 490,657 (289)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Dependence structure of market states

, 2015
We study the dependence structure of market states by estimating empirical pairwise copulas of daily stock returns. We consider both original returns, which exhibit time-varying trends and volatilities, as well as locally normalized ones, where the non ...
Chetalova, Desislava, Schäfer, Rudi, Wollschläger, Marcel   +2 more
core   +1 more source

Rank-normalization, folding, and localization: An improved $\widehat{R}$ for assessing convergence of MCMC

, 2020
Markov chain Monte Carlo is a key computational tool in Bayesian statistics, but it can be challenging to monitor the convergence of an iterative stochastic algorithm.
Bürkner, Paul-Christian, Carpenter, Bob, Gelman, Andrew, Simpson, Daniel, Vehtari, Aki   +4 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Protective Effect of Tiger Nut (Cyperus Esculentus) Against Monosodium Glutamate-Induced Reproductive Dysfunction in Male Wistar Rats

Veterinary Sciences and Practices
Monosodium glutamate (MSG) is a widespread flavour enhancer linked to health risks, including male reproductive dysfunction. This study investigated tiger nut (Cyperus esculentus) as a potential protective agent against MSG-induced reproductive issues in
Abraham Akinyemi, Olumide Ajani, Olumide Akinniyi   +2 more
doaj   +1 more source

Extreme deviations and applications

, 1997
Stretched exponential probability density functions (pdf), having the form of the exponential of minus a fractional power of the argument, are commonly found in turbulence and other areas.
Frisch, U., Sornette, D.
core   +3 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

New FxLMAT-Based Algorithms for Active Control of Impulsive Noise

IEEE Access, 2023
In the presence of non-Gaussian impulsive noise (IN) with a heavy tail, active noise control (ANC) algorithms often encounter stability problems. While adaptive filters based on the higher-order error power principle have shown improved filtering ...
Alina Mirza, Farkhanda Afzal, Ayesha Zeb, Abdul Wakeel, Waqar Shahid Qureshi, Ali Akgul   +5 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calculation of Electron Swarm Parameters in Tetrafluoromethane

ARO-The Scientific Journal of Koya University, 2020
The electron swarm parameters and electron energy distribution function (EEDF) are necessary, especially on understanding quantitatively plasma phenomena and ionized gases.
Idris H. Salih, Mohammad M. Othman, Sherzad A. Taha   +2 more
doaj   +1 more source