Results 61 to 70 of about 1,575,044 (341)

Annual 12‐Week Dosing Gap of Natalizumab: Clinical Efficacy, Blood Biomarkers, and CSF Cell Composition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Natalizumab (NTZ) is a highly effective therapy for multiple sclerosis (MS); however, its use is limited by the risk of a rare potentially severe opportunistic brain infection, progressive multifocal leukoencephalopathy (PML). Alternative dosing strategies are evaluated to reduce PML risk while still maintaining efficacy, which ...
Regina Berkovich   +10 more
wiley   +1 more source

Normative Alethic Pluralism [PDF]

open access: yes, 2018
Some philosophers have argued that truth is a norm of judgement and have provided a variety of formulations of this general thesis. In this paper, I shall side with these philosophers and assume that truth is a norm of judgement.
A Gibbard   +35 more
core   +1 more source

Norms and normativity

open access: yesCalenda, 2017
Collective life is structured by norms. Even though such norms manifest as regularities for those who observe them, they also constitute rules to follow or ideals to mimic. May these norms be social, moral, or legal, they organize practices and orient judgments, especially in the economic sphere.
openaire   +1 more source

On the norm and multiplication principles for norm varieties

open access: yesAnnals of K-Theory, 2020
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Gilat, Shira, Matzri, Eliyahu
openaire   +2 more sources

CSF Levels of NPTX2 Are Associated With Less Brain Atrophy Over Time in Cognitively Unimpaired Individuals

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Neuronal pentraxin 2 (NPTX2) is a synaptic protein involved in synaptic plasticity and regulation of neuronal excitability. Lower baseline cerebrospinal fluid (CSF) NPTX2 levels have been shown to be associated with an earlier onset of mild cognitive impairment (MCI), a pre‐dementia syndrome, even after CSF Alzheimer's Disease (AD)
Juan P. Vazquez   +12 more
wiley   +1 more source

The intersection between Descriptivism and Meliorism in reasoning research: further proposals in support of 'soft normativism' [PDF]

open access: yes, 2014
The rationality paradox centres on the observation that people are highly intelligent, yet show evidence of errors and biases in their thinking when measured against normative standards.
Ackerman   +100 more
core   +3 more sources

Health‐Related Quality of Life in Rare Forms of Childhood‐Onset Hereditary Spastic Paraplegia

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We assessed health‐related quality of life (HRQoL) in 80 children with rare hereditary spastic paraplegias using the Caregiver Priorities and Child Health Index of Life with Disabilities and clinician‐reported outcomes. HRQoL was consistently reduced, particularly in relation to motor, autonomic, and bulbar symptoms.
Henri J. D. Schmidt   +11 more
wiley   +1 more source

Political Thought as Interdisciplinary Knowledge: A Paradigmatic-Implicative Narration [PDF]

open access: yesInterdisciplinary Studies in the Humanities, 2015
Political thought is the kind of thinking which is formulated in different disciplines; political philosophy, political ideology, political theology, and political literature are some of its important examples. Although in the course of history political
A. Manoochehri
doaj   +1 more source

Social norms and human normative psychology [PDF]

open access: yes, 2018
Our primary aim in this paper is to sketch a cognitive evolutionary approach for developing explanations of social change that is anchored on the psychological mechanisms underlying normative cognition and the transmission of social norms.
Davis, Taylor, Kelly, Daniel
core  

The dominance of norms [PDF]

open access: yesActual Problems of Economics and Law, 2015
Objective: to revisit the debate about rational choice theory from the legal, cultural and historical perspectives.Methods: dialectic approach to the cognition of social phenomena, allowing to analyze them in their historical development and functioning in the context of the integrity of subjective and objective factors; this determines the choice of ...
openaire   +2 more sources

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