Results 141 to 150 of about 1,696,544 (312)
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Crime, punishment and social norms [PDF]
We analyze the interplay between economic incentives and social norms when individuals decide whether or not to engage in criminal activity. More specifically, we assume that there is a social norm against criminal activity and that deviations from the ...
Villa, Edgar, Weibull, Jörgen
core
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Norms of valence, arousal, and dominance for 13,915 English lemmas
Behavior Research Methods, 2013 Amy Beth Warriner +2 more
semanticscholar +1 more source
Personal norms of sustainability and their impact on management – The case of rangeland management in semi-arid regions [PDF]
We empirically study personal norms of sustainability, conceptualized according to the normactivation theory and operationalized under the notion of strong ecological-economic sustainability, for commercial cattle farmers in semi-arid rangelands of ...
Stefan Baumgaertner +2 more
core
The Field of Norms Functor and the Hilbert Symbol [PDF]
, 2010 The classical Hilbert symbol of a higher local field $F$ containing a primitive $p^M$-th root of unity $\zeta_M$ is a pairing $F^*/(F^*)^{p^M}\times K_N(F)/p^M \to \mu_{p^M}$, describing Kummer extensions of exponent $p^M$.
JENNI, RUTH,CHRISTINE +1 more
core
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Russian Journal of Economics and Law, 2008 The article comprises research of the act in the Russian State during period from 11-th to the beginning of 20-th centuries, from the Russian Truth up to the Criminal Code of 1903.
I. N. Frolova
doaj