Results 151 to 160 of about 890,913 (263)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Healthy lifestyle culture in universities as institutional normativity: a sociological systematic review. [PDF]

Front Sociol
Tokbergenov Z, Simtikov Z, Seitzhanov D, Abdrassilov A.   +3 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Fertility postponement and age norms in Poland: is there a deadline for parenthood? [PDF]

The postponement of childbearing is occurring across Europe, but the paths of this trend differ profoundly from country to country. Especially in Central and Eastern Europe, most women have their first child at a relatively young age.
Monika A. Mynarska
core  

Construction of norms for the Professional Identity Scale of Nursing Undergraduates in China

Huli yanjiu
ObjectiveTo establish norms for the Professional Identity Scale of nursing undergraduates in China.MethodsUsing the Professional Identity Scale for nursing students as the assessment tool,a stratified cluster sampling method was adopted to survey 26 108 ...
LI Xiaohua, ZHU Hong, LIU Yu, TIAN Runxi, GAO Ning   +4 more
doaj  

Intragroup Judgements of Norm Violators Under the Threat of COVID-19. [PDF]

Behav Sci (Basel)
Sinclair-Thompson A, Hunter JA.
europepmc   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

A study on medical students' willingness to participate in academic assessment and its influencing factors under the "New Medical Science" initiative. [PDF]

Front Psychol
Yu G.
europepmc   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Contextualized sensorimotor norms: Multi-dimensional measures of sensorimotor strength for ambiguous English words, in context. [PDF]

Behav Res Methods
Trott S, Bergen B.
europepmc   +1 more source