Results 141 to 150 of about 132,245 (266)

A sclerochronology defined 600-year baseline of marine dynamics in the North Sea. [PDF]

Philos Trans R Soc Lond B Biol Sci
Reynolds D, Genelt-Yanovskiy E, Genelt-Yanovskaya A, Northey E, Butler P, Trofimova T, Conti M, Penkman K, Huang Q, Schöne B, Scourse J.   +10 more
europepmc   +1 more source

Acoustic monitoring reveals spatiotemporal occurrence of Nathusius' pipistrelle at the southern North Sea during autumn migration. [PDF]

Environ Monit Assess, 2023
Lagerveld S, Wilkes T, van Puijenbroek MEB, Noort BCA, Geelhoed SCV.   +4 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Persistent Infection in Harbor Seals 12-13 Years after Phocine Distemper Virus Epizootics in 1988 and 2002, North Sea. [PDF]

Emerg Infect Dis
van de Bildt MWG, Rijks JM, Jensen TH, Brasseur SMJM, Kik MJL, Osterhaus ADME, Gröne A, Kuiken T, IJzer J.   +8 more
europepmc   +1 more source

A typology of North Sea oil and gas platforms. [PDF]

Sci Rep, 2022
Lawrence JM, Fernandes PG.
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

A novel North Sea ammonia-oxidizing archaeon Nitrosarchaeum marinum leverages a high abundance of transport systems to grow over a wide salinity range. [PDF]

FEMS Microbiol Ecol
Lüke C, Haaijer SCM, Bespiatykh D, Speth DR, Mesman R, Jetten MSM, Op den Camp HJM, Lücker S, Lehtovirta-Morley LE.   +8 more
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Long-range pollen transport across the North Sea: Insights from migratory hoverflies landing on a remote oil rig. [PDF]

J Anim Ecol
Doyle TD, Jimenez-Guri E, Barnes JC, Hannah C, Murray S, Wyatt CDR, Poole OM, Wotton KR.   +7 more
europepmc   +1 more source

Offshore Wind Energy and Marine Biodiversity in the North Sea: Life Cycle Impact Assessment for Benthic Communities. [PDF]

Environ Sci Technol, 2023
Li C, Coolen JWP, Scherer L, Mogollón JM, Braeckman U, Vanaverbeke J, Tukker A, Steubing B.   +7 more
europepmc   +1 more source