Results 131 to 140 of about 1,756,097 (306)

Lagrangian View of Atlantic Water Pathways toward the North Sea

open access: yesTellus: Series A, Dynamic Meteorology and Oceanography
The influence of subpolar North Atlantic hydrographic conditions on the North Sea is well recognized, yet the precise pathways taken by Atlantic Water to reach its gateway remain uncertain.
Léon Chafik   +2 more
doaj   +1 more source

PICES Press, Vol. 6, No. 2, July 1998 [PDF]

open access: yes, 1998
CREAMS, PICES and the exploration of the Japan/East Sea The state of the eastern North Pacific from September 97 to February 98 The state of the western North Pacific in the second half of 1997 The status of the Bering Sea in the second half of ...

core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov   +3 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

Neoglacial cooling culminates in rapid sea ice oscillations in eastern Fram Strait [PDF]

open access: yes, 2011
EGU2011-407 The spatial and temporal distribution of sea ice in the subpolar North Atlantic is mainly controlled by the advection of warm Atlantic Water via the Norwegian and West Spitsbergen Current in eastern Fram Strait.
Müller, Juliane   +3 more
core  

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Carbon dioxide Storage Potential in the North Sea [PDF]

open access: yes, 2010
Imperial Users ...
Chamwudhiprecha, Nalinee   +1 more
core  

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Controls on zooplankton assemblages in the northeastern Chukchi Sea [PDF]

open access: yes, 2016
Thesis (Ph.D.) University of Alaska Fairbanks, 2016The Chukchi Sea is a broad and shallow marginal sea of the western Arctic Ocean that lies between the Bering Sea and the deeper Amerasian basin.
Questel, Jennifer
core  

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