Results 111 to 120 of about 1,756,097 (306)

Inhibitory Effects of Two Kinds of Microplastics on the Growth of Skeletonema costatum

Haiyang Kaifa yu guanli
As a new pollutant, microplastics may have an impact on the growth and photosynthesis of marine phytoplankton. In order to study the growth inhibitory effect of microplastics on the Skeletonema costatum in marine phytoplankton, the paper adopts light ...
YU Mingru, GUO Hui, WU Jianping
doaj  

Projected change - North Sea

, 2016
Increasing numbers of regional climate change scenario assessments have become available for the North Sea. A critical review of the regional studies has helped identify robust changes, challenges, uncertainties and specific recommendations for future research.
Schrum, Corinna, Lowe, Jason, Meier, H.E. Markus, Grabemann, Iris, Holt, Jason, Mathis, Moritz, Pohlmann, Thomas, Skogen, Morten D., Sterl, Andreas, Wakelin, Sarah   +9 more
openaire   +3 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Economic viability assessment of European flat oyster restoration on offshore windfarm infrastructure

Aquatic Living Resources
European oysters (Ostrea edulis) once covered large areas of the North Sea, but have disappeared due to a combination of overexploitation and the destruction of benthic habitats including hard settlement substrate.
Jacobs Pascalle, van der Hiele Tony, Heringa Jouke, Verbeeke Gabrielle P., Tonk Linda, ter Hofstede Remment, van Houcke Jasper   +6 more
doaj   +1 more source

The North Sea

, 2017
Chapter 7 in the 'SPLASHCOS Taphonomy book', on the landscape-archaeological inventory of the North Sea as a regional sea (covering British, Dutch, Belgian, German and Danish sectors of the southern and central North Sea). Abstract: This chapter gives a general overview of knowledge regarding the North Sea area in the context of Quaternary prehistory ...
Cohen, K.M., Westley, K., Erkens, G., Hijma, M.P., Weerts, H.J.T.   +4 more
openaire   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Spatial Hedonic Models for Measuring the Impact of Sea-Level Rise on Coastal Real Estate [PDF]

This study uses a unique integration of geospatial and hedonic property data to estimate the impact of sea-level rise on coastal real estate in North Carolina.
Ben Poulter, Christopher F. Dumas, John C. Whitehead, Okmyung Bin   +3 more
core  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source