Results 101 to 110 of about 1,756,097 (306)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Chromosome-level genome provides new insights into the fatty acid biosynthesis and metabolism of the sea urchin Strongylocentrotus intermedius

BMC Genomics
Polyunsaturated fatty acids (PUFAs) are important nutrients that play critical roles in sea urchin reproduction and early development. Strongylocentrotus intermedius, the only commercially cultured sea urchin species in China with substantial economic ...
Lingshu Han, Jun Ding, Heng Wang, Yang Zhang, Junxiao Sun, Chong Zhao, Weijie Zhang, Rantao Zuo, Wenpei Wang, Ye Tian, Yaqing Chang   +10 more
doaj   +1 more source

Forming perceptions and the limits to public participation on ocean commons: evidence from a citizens jury workshop

International Journal of the Commons, 2017
This article presents data from a citizens jury-inspired deliberative workshop held to tease out stakeholder views of management priorities for a section of the North Sea: the Dogger Bank. As this article reveals, the lessons learned from the Dogger Bank
Alyne Elizabeth Delaney, Maria Hadjimichael   +1 more
doaj   +1 more source

Effects of the oceans on polar motion: Continued investigations [PDF]

Data on the pole tide, the oceanic response to the Chandler wobble were presented. Observed North Sea pole tide enhancement (i.e., larger amplitudes than a static tide would possess) resulted from bottom friction, with the drag coefficient, in ...
Dickman, S. R.
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Research on the Value Realization Mechanism of Ecological Products in Rizhao National Marine Park

Haiyang Kaifa yu guanli
Rizhao National Ocean Park is the national level ocean park with the largest area, the most abundant landscape elements and the most complete tourism facilities in China.
LIU Yingying, WANG Zhenzhen, DING Sen, HOU Jiling   +3 more
doaj  

Redescription of Parophryotrocha isochaeta (Eliason, 1962) and a new species of Parophryotrocha (Polychaeta: Dorvilleidae) from the Skagerrak and North Sea

Scientia Marina, 2006
The original description of Parophryotrocha isochaeta (Eliason, 1962; as Ophryotrocha (?) isochaeta) was based on three specimens collected in the deepest part of the Skagerrak in 1933.
Eivind Oug
doaj   +1 more source

Can the North Sea Still Save Europe? [PDF]

In the 1980s and 1990s the North Sea emerged as a key non-OPEC oil producing province. Yet today overall production is declining, in both the British and Norwegian sectors and the big oil companies and investors are losing interest in what they now see ...
Carole Nakhle
core  

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source