Results 101 to 110 of about 5,116,076 (231)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Chromosome-level genome provides new insights into the fatty acid biosynthesis and metabolism of the sea urchin Strongylocentrotus intermedius

BMC Genomics
Polyunsaturated fatty acids (PUFAs) are important nutrients that play critical roles in sea urchin reproduction and early development. Strongylocentrotus intermedius, the only commercially cultured sea urchin species in China with substantial economic ...
Lingshu Han, Jun Ding, Heng Wang, Yang Zhang, Junxiao Sun, Chong Zhao, Weijie Zhang, Rantao Zuo, Wenpei Wang, Ye Tian, Yaqing Chang   +10 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Miocene vegetation and climate in the eastern North Sea Basin, onshore Denmark, compared to the present

GEUS Bulletin
Despite often being referred to as a ‘coolhouse climate’, the climate during the Miocene (23.03–5.33 Ma) was overall humid, warm and temperate. It was paced by orbitally driven cooler periods (the Oligocene–Miocene Transition and Mi-events) overprinted ...
Kasia K. Śliwińska, Thomas Denk, Karen Dybkjær, Julie Margrethe Fredborg, Sofie Lindström, Stefan Piasecki, Erik Skovbjerg Rasmussen   +6 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Systemic Dilemmas and Collaborative Optimization Paths of the Industrial Layout of the Bohai Rim Port Cluster From the Perspective of Land-Sea Coordination

Haiyang Kaifa yu guanli
The article focuses on the Bohai Rim Port Cluster, employing a comparative analysis approach based on the theory of land-sea coordination and regional coordination to thoroughly examine the current industrial layout and development characteristics of ...
GAO Kun, HAN Yu, DU Guangxun, LIU Guochong, GU Bei, ZHAO Yuhui   +5 more
doaj  

Lagrangian View of Atlantic Water Pathways toward the North Sea

Tellus: Series A, Dynamic Meteorology and Oceanography
The influence of subpolar North Atlantic hydrographic conditions on the North Sea is well recognized, yet the precise pathways taken by Atlantic Water to reach its gateway remain uncertain.
Léon Chafik, Ezra Eisbrenner, Kristofer Döös   +2 more
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Spatial Distribution of Nutrients and the Potential Limitation for Phytoplankton Growth in the Coastal Waters of Haiyang

Haiyang Kaifa yu guanli
Based on the 2019 seasonal survey data of seawater nutrients, this study analyzed the concentration characteristics and spatial distribution patterns of nutrients, and assessed the limiting effects of nitrogen, phosphorus, and silicon nutrients on ...
LIU Xiaodan, ZHANG Kun, LIU Shujun, WU Siqi   +3 more
doaj  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source