Results 91 to 100 of about 5,116,076 (231)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Machine learning-based assessment of offshore wind farm impacts on soft-bottom benthic communities in the Shandong Peninsula

Scientific Reports
Offshore wind power, as a crucial component of clean energy, is rapidly expanding globally; however, the long-term impact mechanisms on marine benthic ecosystems remain unclear.
Lan Wang, Yongqiang Zhang, Xueji Gu, Liang Zhang, Haizhou Zhang, Kai Su, Chuanting Zhao   +6 more
doaj   +1 more source

Seasonal Variation in Zooplankton Community Structure and Its Environmental Drivers in the Coastal Waters of Lanshan Port

Biology
Coastal port ecosystems serve as critical interfaces between marine environments and anthropogenic activities, yet zooplankton community dynamics in these transitional zones remain poorly understood.
Liang Zhang, Lan Wang, Cong Fang, Yinglu Ji, Sichao Pu, Huihui Tao, Haizhou Zhang, Yumeng Liu   +7 more
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Research on the Value Realization Mechanism of Ecological Products in Rizhao National Marine Park

Haiyang Kaifa yu guanli
Rizhao National Ocean Park is the national level ocean park with the largest area, the most abundant landscape elements and the most complete tourism facilities in China.
LIU Yingying, WANG Zhenzhen, DING Sen, HOU Jiling   +3 more
doaj  

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Inhibitory Effects of Two Kinds of Microplastics on the Growth of Skeletonema costatum

Haiyang Kaifa yu guanli
As a new pollutant, microplastics may have an impact on the growth and photosynthesis of marine phytoplankton. In order to study the growth inhibitory effect of microplastics on the Skeletonema costatum in marine phytoplankton, the paper adopts light ...
YU Mingru, GUO Hui, WU Jianping
doaj  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source