Results 81 to 90 of about 1,756,097 (306)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Benthic Species Distribution Linked to Morphological Features of a Barred Coast

Journal of Marine Science and Engineering, 2019
The composition of benthic species communities in the nearshore zone is closely related to the hydrodynamic and morphodynamic conditions. Sustainable management of the coastal ecosystem requires knowledge about the natural dynamics as well as human ...
Harriëtte Holzhauer, Bas W. Borsje, Jan A. van Dalfsen, Kathelijne M. Wijnberg, Suzanne J.M.H. Hulscher, Peter M.J. Herman   +5 more
doaj   +1 more source

Recent changes in the surface salinity of the North Atlantic subpolar gyre [PDF]

, 2002
Sea surface salinity (SSS) was measured since 1896 along 60°N between Greenland and the North Sea and since 1993 between Iceland and Newfoundland. Along 60°N away from the shelves, and north of 53°N, the amplitude of the seasonal cycle is comparable to ...
Bacon, Bacon, Bauer, Belkin, Belkin, Bersch, Bojariu, Bretherton, Caniaux, Curry, Dickson, Dickson, Ducet, Eden, Eden, Esselborn, F. Schott, Fabien Durand, Gammelsrød, Gammelsrød, Gilles Reverdin, H. Valdimarsson, Hansen, Hilmer, Häkkinen, Häkkinen, Häkkinen, John Mortensen, Knudsen, Koltermann, Kushnir, Kwok, Lavender, Lazier, Levitus, Levitus, Marsden, Mauritzen, Mysak, Reverdin, Reverdin, Reverdin, Smed, Sutton, Taylor, Verbrugge, Vinje, W. Zenk   +47 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Research on the Spacing Management of Submarine Cables and Pipelines

Haiyang Kaifa yu guanli
Establishing unified monitoring standards, effective metrological assurance for instruments, and accreditation and certification of institutional monitoring capabilities, as well as constructing a systematic marine quality infrastructure, constitute ...
LIU Xiaodan, ZHOU Bin, ZHANG Likui, ZHANG Xiaoju, ZHANG Kun, WANG Yu   +5 more
doaj  

On the Nearshore Significant Wave Height Inversion from Video Images Based on Deep Learning

Journal of Marine Science and Engineering
Accurate observation of nearshore waves is crucial for coastal safety. In this study, the feasibility of extracting wave information from wave video images captured by shore-based cameras using deep learning methods was explored, focusing on inverting ...
Chao Xu, Rui Li, Wei Hu, Peng Ren, Yanchen Song, Haoqiang Tian, Zhiyong Wang, Weizhen Xu, Yuning Liu   +8 more
doaj   +1 more source

Sea Bed Sand Waves Studied To Help Pipeline Planners [PDF]

, 2008
The article cites a study that offers information on the variability of sand wave characteristics in the North Sea. The sand waves variability includes a statement that pipelines may start vibrating due to turbulence generated under the free span and ...
Blom, A., Hulscher, S.J.M.H., Koning, M.F. de, Mark, C.F. van der, Stolk, A.   +4 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source