Results 151 to 160 of about 1,748,176 (291)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Research on Quality Management Information System for Marine Ecological Early Warning Monitoring Throughout the Process

Haiyang Kaifa yu guanli
Based on operational requirements for quality management, an information technology platform is designed and developed, which covers the entire business process of marine ecological early warning and monitoring, by applying technologies such as SOA ...
ZHENG Lin, SONG Xiaoli, YANG Xiaofei, ZHOU Chunyin, WEN Tingting, YUAN Yuan, HAN Xixi   +6 more
doaj  

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Identifying and addressing the anthropogenic drivers of global change in the North Sea: a systematic map. [PDF]

Environ Evid
Blöcker AM, Auch D, Gutte HM, Biederbick J, Asselot R, Färber L, Börner G, Kamberi E, Madiraca F, Ofelio C, Steidle L, Moullec F.   +11 more
europepmc   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Advancing long-term phytoplankton biodiversity assessment in the North Sea using an imaging approach. [PDF]

Sci Data
Lagaisse R, Dillen N, Bakeev D, Decrop W, Focke P, Mortelmans J, Muyle J, Deneudt K.   +7 more
europepmc   +1 more source

Benthic microbial biogeographic trends in the North Sea are shaped by an interplay of environmental drivers and bottom trawling effort. [PDF]

ISME Commun, 2023
Bonthond G, Beermann J, Gutow L, Neumann A, Barboza FR, Desiderato A, Fofonova V, Helber SB, Khodami S, Kraan C, Neumann H, Rohde S, Schupp PJ.   +12 more
europepmc   +1 more source

Estimation of Production Functions on Fishery: A Danish Survey [PDF]

The fishing fleet and the component parts of effort and production can be de-scribed and analysed in different ways. As an example, the fishing fleet can be described using a list of different production function specifications.
Ayoe Hoff, Birgit Nahrstedt, Henning P. Jørgensen   +2 more
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Fatty Acids and Stomach Contents Reveal Dietary Overlaps of Two Prospering Squid Species in the North Sea. [PDF]

Ecol Evol
Rittinghaus H, Saborowski R, Kammann UKR, Oesterwind D, Sell AF.   +4 more
europepmc   +1 more source