Results 81 to 90 of about 1,748,176 (291)
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Aquaculture NutritionA 114-day feeding trial was used to investigate the influence of vitamin A (VA) on growth performance, nonspecific immune responses and shell microbiota in juvenile sea urchin (Strongylocentrotus intermedius).
Dan Gou +8 more
doaj +1 more source
Aquatic Living ResourcesEuropean oysters (Ostrea edulis) once covered large areas of the North Sea, but have disappeared due to a combination of overexploitation and the destruction of benthic habitats including hard settlement substrate.
Jacobs Pascalle +6 more
doaj +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Characteristics of Plankton Population Structure in Coastal Waters in Rizhao City in 2021
Haiyang Kaifa yu guanliBy analyzing the species composition, distribution, quantity and changes of phytoplankton and zooplankton in the coastal waters of Rizhao City in May and August 2021, this paper provides technical support for comprehensively understanding the status and ...
LIU Yingying +4 more
doaj
Ventilation of the North Atlantic Ocean during the Last Glacial Maximum: A comparison between simulated and observed radiocarbon ages [PDF]
, 2003 The distribution of radiocarbon during simulations of the Last Glacial Maximum with a coupled ocean-atmosphere-sea ice model is compared with sediment core measurements from the equatorial Atlantic Ceara Rise, Blake Ridge, Caribbean Sea, and South China ...
Adkins, J. F. +3 more
core +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source