Results 81 to 90 of about 54,464 (302)
BMC Cancer, 2011 Background Gastric cancer is the second most common cause of global cancer-related mortality. Although dedifferentiation predicts poor prognosis in gastric cancer, the molecular mechanism underlying dedifferentiation, which could provide fundamental ...
Zhu Zhenggang +9 more
doaj +1 more source
Advanced Science, EarlyView.The plant hormone jasmonate is perceived by COI1‐JAZ co‐receptors comprising a single F‐box protein COI1 and multiple JAZ repressors with overlapping functions, complicating genetic analysis. We present a reactive antagonist (RA) strategy that selectively promotes COI1 binding to a cysteine‐engineered JAZ variant while blocking wild‐type JAZs, enabling
Minoru Ueda +10 more
wiley +1 more source
SMALL NONCODING RNA AS PERSPECTIVE BIOMARKERS: BIOGENESIS AND THERAPEUTIC STRATIGIES
Бюллетень сибирской медицины, 2016 The review presents the opening story, biogenesis and functions of basic groups of human’s small noncoding RNA: microRNA and short interfering RNA. These RNA molecules inhibit gene expression during translation by RNA interference.
V. V. Tiguntsev +3 more
doaj +1 more source
Cancer cells overexpress mRNA of urokinase-type plasminogen activator, its receptor and inhibitors in human non-small-cell lung cancer tissue: Analysis by Northern blotting andin situ hybridization [PDF]
, 1998 Sumihito Morita +6 more
openalex +1 more source
Advanced Science, EarlyView.We delineate a TGFβ1/SMAD/lnc‐APUE/E‐cadherin axis wherein TGFβ1 signaling activates lnc‐APUE; lnc‐APUE subsequently downregulates E‐cadherin expression via Alu element‐driven STAU1‐mediated decay of CDH1 mRNA, thereby promoting tumor metastasis. Our findings reveal a novel regulatory function for lnc‐APUE within the SMD pathway, elucidate a distinct ...
Song‐Yang Li +10 more
wiley +1 more source
Northern blot detection of endogenous small RNAs ( 14 nt) in bacterial total RNA extracts [PDF]
, 2010 Benedikt M. Beckmann +3 more
openalex +1 more source
Engineered CAR‐NKT Extracellular Vesicles Suppress Tumor Progression and Enhance Antitumor Immunity
Advanced Science, EarlyView.TM4SF1‐nanobody engineered CAR‐natural killer T–derived extracellular vesicles (CARTM4SF1‐EVs) provide a cell‐free alternative to CAR‐NKT therapy, achieving potent, targeted antitumor activity with reduced toxicity. CARTM4SF1‐EVs induce immunogenic cell death, remodel the tumor microenvironment, and enhance CD8⁺ T‐cell antitumor immunity.
Xiaopei Hao +14 more
wiley +1 more source
SRSF1 inhibits HBV replication by enhancing the stability of P53 in cell models
陆军军医大学学报Objective To investigate the effect and underlying mechanism of serine and arginine rich splicing factor 1 (SRSF1) on the replication of hepatitis B virus (HBV).
LIU Jiajun +3 more
doaj +1 more source
Multiplexed miRNA northern blots via hybridization chain reaction [PDF]
, 2016 Maayan Schwarzkopf, Niles A. Pierce
openalex +1 more source
Quantitative proteomics identifies clusterin as a novel biomarker for atherosclerosis
Animal Models and Experimental Medicine, EarlyView.This schematic illustrates the proposed mechanism. In advanced atherosclerotic lesions, upregulated CLU on the cell surface activates low‐density lipoprotein (LDL) receptor‐related protein 1 (LRP1). This interaction triggers the phosphorylation and activation of AKT.
Dengfeng Ding +10 more
wiley +1 more source