Results 91 to 100 of about 346,758 (357)

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

open access: yesAdvanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang   +15 more
wiley   +1 more source

An audit of Ear, Nose and Throat diseases in a tertiary health institution in South-western Nigeria

open access: yesThe Pan African Medical Journal, 2013
INTRODUCTION: This study is aimed at determining the pattern of ear, nose and throat diseases and their relationship with socio-demographic factors with auditing intent in a tertiary hospital in South-western Nigeria. METHODS: Medical records of patients
Ayotunde James Fasunla   +2 more
doaj   +1 more source

A Review on Biodegradable Materials of Sustainable Soft Robotics and Electronics

open access: yesAdvanced Science, EarlyView.
Biodegradable materials are gaining increasing attention in soft robotics and electronics due to their environmental friendliness, showing great potential for sustainability. In this review, the classification of biodegradable materials, their applications in the field of soft robotics and electronics, as well as the challenges and future prospects ...
Yizhu Xie   +8 more
wiley   +1 more source

'Bochanan modhail foghlaimte': Tiree Gaelic, lexicology and Glasgow's historical dictionary of Scottish Gaelic [PDF]

open access: yes, 2008
The present paper is intended as a modest contribution towards the study of Tiree Gaelic, particularly its lexicon, drawing on a small part of the archives of the Historical Dictionary of Scottish Gaelic (HDSG) held in the Department of Celtic ...
Ó Maolalaigh, R.
core  

Genomics Insights Into High‐Latitude Adaptation of Tibetan Macaques

open access: yesAdvanced Science, EarlyView.
Tibetan macaques exhibit unique adaptations to cold, high‐latitude environments, including shortened tails and enhanced fat storage. Genomic analyses reveal a species‐specific TBX6 mutation linked to tail reduction and selection on lipid metabolism genes.
Rusong Zhang   +12 more
wiley   +1 more source

Lung Cancer Screening Based on Type-different Sensor Arrays

open access: yesScientific Reports, 2017
In recent years, electronic nose (e-nose) systems have become a focus method for diagnosing pulmonary diseases such as lung cancer. However, principles and patterns of sensor responses in traditional e-nose systems are relatively homogeneous.
Wang Li   +4 more
doaj   +1 more source

CircTspan3 Promotes Cartilage Development Through ANNEXIN A2‐Mediated Ferroptosis and Apoptosis Inhibition and Exosome‐Mediated Paracrine Signaling

open access: yesAdvanced Science, EarlyView.
This study reveals that XBP1s drives production of circTspan3, a circular RNA that strengthens cartilage by boosting anabolic activity and limiting cell death. Phosphorylated ANXA2 directs circTspan3 into exosomes, enabling paracrine repair. Exosomal circTspan3 expands growth‐plate cartilage and promotes in vivo regeneration, highlighting its promise ...
Yiming Pan   +16 more
wiley   +1 more source

CD20+FCRL4+ B Cells Activate CD8+ T Cells via MHC‐I Restriction in Nasopharyngeal Carcinoma Anti‐Tumor Immunity

open access: yesAdvanced Science, EarlyView.
CD20⁺FCRL4⁺ B cells in nasopharyngeal carcinoma actively cross‐present exogenous tumor antigens via MHC‐I, enhancing CD8⁺ T‐cell activation, memory formation, and cytotoxicity. IFNγ‐driven WDFY4 upregulation facilitates this process. These findings reveal an unconventional B‐cell–mediated antitumor mechanism and indicate potential relevance to ...
Benjian Zhang   +17 more
wiley   +1 more source

Syringocystadenoma Papilliferum of the Bony External Auditory Canal: A Rare Tumor in a Rare Location

open access: yesCase Reports in Otolaryngology, 2013
Tumors originating from ceruminous glands are rare lesions of the external auditory canal. The lack of specific clinical and radiological signs makes their diagnosis challenging.
Anastasija Arechvo   +3 more
doaj   +1 more source

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