Results 101 to 110 of about 261,437 (315)
eLife, 2016 β-selection is the most pivotal event determining αβ T cell fate. Here, surface-expression of a pre-T cell receptor (pre-TCR) induces thymocyte metabolic activation, proliferation, survival and differentiation.
Luise Westernberg +9 more
doaj +1 more source
"Notch-Off": a perspective on the termination of Notch signalling
The International Journal of Developmental Biology, 2009 During Notch mediated lateral inhibition, interacting cells establish or amplify differences in Notch signalling, which are then translated into distinct cell fate decisions according to the developmental context. In recent years, several mechanisms that increase the signalling capacity of interacting cells have been uncovered (reviewed in Bray, 2006 ...
Rita, Fior, Domingos, Henrique
openaire +3 more sources
Advanced Engineering Materials, EarlyView.Phase‐field simulations coupled with dislocation‐density‐based crystal plasticity modeling reproduce γ′ rafting behavior in single‐crystal Ni‐based superalloys under varied loading conditions. The model captures both macroscopic creep and microscopic morphology evolution, with results matching high‐temperature creep experiments.
Micheal Younan +5 more
wiley +1 more source
Notch2 signaling in development and cancer [PDF]
, 2012 Notch signaling via cell to cell interaction is a key mechanism in regulating proliferation, cell fate decisions and survival of various cell types in both invertebrates and vertebrates.
Tchorz, Jan Stephan
core +1 more source
Special Issue on Fracture and Fatigue Assessments of Structural Components
Applied Sciences, 2020 This Special Issue covers the broad topic of structural integrity of components subjected to either static or fatigue loading conditions, and it is concerned with the modelling, assessment and reliability of components of any scale. Dealing with fracture
Alberto Campagnolo
doaj +1 more source
Karl Popper and the Mechanisms of Hydrogen Embrittlement
Advanced Engineering Materials, EarlyView.Representation of the beginning of loss of ductility rather than embrittlement. Small concentrations of hydrogen in a diffusible form within iron are well‐established to harm the mechanical integrity of steels. There are theories that attempt to explain the pernicious role of hydrogen.
H. K. D. H. Bhadeshia
wiley +1 more source
Inhibition of Gamma-Secretase Promotes Axon Regeneration After a Complete Spinal Cord Injury
Frontiers in Cell and Developmental Biology, 2020 In a recent study, we showed that GABA and baclofen (a GABAB receptor agonist) inhibit caspase activation and promote axon regeneration in descending neurons of the sea lamprey brainstem after a complete spinal cord injury (Romaus-Sanjurjo et al., 2018a).
Daniel Sobrido-Cameán +6 more
doaj +1 more source
Advanced Engineering Materials, EarlyView.A two‐dimensional multiscale finite element analysis framework was established for the first‐generation MoSiBTiC alloy, and the mechanical and fracture‐related parameters of the constituent phases were calibrated through experiments and simulations. The framework provides a basis for analyzing crack propagation behavior in its complex microstructure ...
Junfeng Du +4 more
wiley +1 more source
A Fully Adaptive Lattice-based Notch Filter for Mitigation of Interference in GPS [PDF]
, 2019 Intentional interference presents a major threat to the operation of the Global Navigation Satellite Systems. Adaptive notch filtering provides an excellent countermeasure and deterrence against narrowband interference.
Syed Waqas Arif +5 more
core +1 more source
Designing a Compact Microstrip Antenna Using the Machine Learning Approach
Journal of Telecommunications and Information Technology, 2020 This paper presents how machine learning techniques may be applied in the process of designing a compact dual-band H-shaped rectangular microstrip antenna (RMSA) operating in 0.75–2.20 GHz and 3.0–3.44 GHz frequency ranges.
Kanhaiya Sharma, Ganga Prasad Pandey
doaj +1 more source