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Notches. [PDF]

open access: possibleAmerican Economic Review, 1984
Economists have an instinctively negative reaction to any government program that creates a "notch," that is, a discontinuity in a budget constraint. For example, welfare programs like public housing are structured so that a finite lump of benefits is lost all at once when a household's income crosses a certain threshhold.
Alan S. Blinder, Harvey S. Rosen
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Kernohan's notch

Practical Neurology, 2015
A 55-year-old woman, previously well, attended the emergency department with a 1-year history of falls, increasing dizziness, memory loss, personality change and poor concentration affecting certain activities, such as reading and puzzles. She attended a psychiatric clinic because of panic attacks and depression relating to her husband's ill health and
Jose Luis Camacho, Velasquez   +3 more
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Notch Signaling

Science, 1995
The Notch/Lin-12/Glp-1 receptor family mediates the specification of numerous cell fates during development in Drosophila and Caenorhabditis elegans . Studies on the expression, mutant phenotypes, and developmental consequences of unregulated receptor activation have implicated these proteins
S, Artavanis-Tsakonas   +2 more
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Notch and Senescence

2018
Cellular senescence, previously thought of as an autonomous tumour suppressor mechanism, is emerging as a phenotype and effector present throughout the life of an organism from embryogenesis to senile decline. Senescent cells have powerful non-autonomous effects upon multiple players within their microenvironment mainly through their secretory ...
Hoare, Matthew, Narita, Masashi
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Notch and neurogenesis

Journal of Neuroscience Research, 1998
The Notch signaling pathway has during the last few years emerged as an important signaling mechanism for communication between neighboring cells. Many of the components in the Notch signaling pathway have been identified and the pathway is important for cellular differentiation in various organs, including the nervous system.
P, Beatus, U, Lendahl
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Notch in Leukemia

2018
Notch is commonly activated in lymphoid malignancies through ligand-independent and ligand-dependent mechanisms. In T-cell acute lymphoblastic leukemia/lymphoma (T-ALL), ligand-independent activation predominates. Negative Regulatory Region (NRR) mutations trigger supraphysiological Notch1 activation by exposing the S2 site to proteolytic cleavage in ...
Anna C, McCarter   +2 more
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Notch to remember

Trends in Neurosciences, 2005
Some of the signaling molecules required for formation of long-term memories are involved primarily in adult brain function, but others participate in a variety of other biological processes. The Notch signaling pathway, which is important for cell fate specification and differentiation in various systems, is also active in the mature brain.
Rui M, Costa   +2 more
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Notch and Neurogenesis

2018
Neurogenesis is the process of forming neurons and is essential during vertebrate development to produce most of the neurons of the adult brain. However, neurogenesis continues throughout life at distinct locations in the vertebrate brain. Neural stem cells (NSCs) are the origin of both embryonic and adult neurogenesis, but their activity and fate are ...
Engler A, Zhang R, Taylor V
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Notch in vertebrates

Current Opinion in Genetics & Development, 1997
Homologs of the Notch receptor and its ligands participate in cell fate decisions during vertebrate development. The past year has seen significant advances in knowledge of the role of Notch in Xenopus neuronal development and T-cell development and in our understanding of the Notch signalling pathway in vertebrates.
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Deciphering Notch signaling notch by notch

Cell Signaling, 2023
Lidia Borkiewicz, Adolfo Rivero-Müller
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