Results 271 to 280 of about 118,516 (288)
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Ubiquitination of Notch1 is regulated by MAML1-mediated p300 acetylation of Notch1
Biochemical and Biophysical Research Communications, 2011Earlier studies demonstrated the involvement of the p300 histone acetyltransferase in Notch signaling but the precise mechanisms by which p300 might modulate Notch function remains to be investigated. In this study, we show that p300 acetylates Notch1 ICD in cell culture assay and in vitro, and conserved lysines located within the Notch C-terminal ...
Anita E, Popko-Scibor +4 more
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NOTCH1 modulates activity of DNA-PKcs
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2018DNA-dependent protein kinase catalytic subunit (DNA-PKcs) controls one of the most frequently used DNA repair pathways in a cell, the non-homologous end joining (NHEJ) pathway. However, the exact role of DNA-PKcs in NHEJ remains poorly defined. Here we show that NOTCH1 attenuates DNA-PKcs-mediated autophosphorylation, as well as the phosphorylation of ...
Adamowicz M +2 more
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Notch1 regulates hepatic thrombopoietin production
BloodAbstract Notch signaling regulates cell-fate decisions in several developmental processes and cell functions. However, the role of Notch in hepatic thrombopoietin (TPO) production remains unclear. We noted thrombocytopenia in mice with hepatic Notch1 deficiency and so investigated TPO production and other features ...
Yueyue Sun +15 more
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Site-specific methylation of Notch1 controls the amplitude and duration of the Notch1 response
Science Signaling, 2015Methylation of the active Notch cleavage product promotes its degradation to produce short periods of Notch signaling necessary for proper development.
K. Hein +11 more
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Cell Biology International, 2011
The Notch signalling pathway regulates proliferation, cell death and cell type specification that is critical for organogenesis. Mouse models carrying mutations in the Notch signalling pathway display defects in development of the placenta, suggesting that this pathway is required for placental development.
Didem Pelin, Sarikaya +1 more
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The Notch signalling pathway regulates proliferation, cell death and cell type specification that is critical for organogenesis. Mouse models carrying mutations in the Notch signalling pathway display defects in development of the placenta, suggesting that this pathway is required for placental development.
Didem Pelin, Sarikaya +1 more
openaire +2 more sources
Archives of Gynecology and Obstetrics, 2015
Notch signalings are regulated multiple cellular processes during cancer progression. We aimed to investigate the significance and prognostic value of expression of Notch1 and JAG1 in cervical cancer to determine whether they could serve as prognostic predictors.The expression of Notch1/JAGD1 was investigated by real-time PCR, western blot assay and ...
Nasser Ghaly, Yousif +5 more
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Notch signalings are regulated multiple cellular processes during cancer progression. We aimed to investigate the significance and prognostic value of expression of Notch1 and JAG1 in cervical cancer to determine whether they could serve as prognostic predictors.The expression of Notch1/JAGD1 was investigated by real-time PCR, western blot assay and ...
Nasser Ghaly, Yousif +5 more
openaire +2 more sources
“Cryptic” Notch1 messages induce T-ALL
Blood, 2010In this issue of Blond, 2 articles define a new class of somatic mutations that allow transcription of oncogenic Notch 1 from cryptic internal promoters.
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Notch1 mutations drive clonal expansion in normal esophageal epithelium but impair tumor growth
Nature Genetics, 2023Stefan Dentro +2 more
exaly
Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia
Nature Medicine, 2007Teresa Palomero +2 more
exaly