Results 281 to 290 of about 110,460 (323)

CRISPR-Cas9 screening identifies ATOX1-driven cisplatin resistance mechanisms in liver cancer and evaluates targeted inhibitor efficacy. [PDF]

Commun Biol
Hu C, Tai H, Zhu R, Shu Z, Guo G, Ma D, Zuo S, Tang L, Zeng Z.   +8 more
europepmc   +1 more source

Multiomics profiling and experiments in preclinical models revealed RAD51-IN-1 as a synergistic potentiator of anlotinib sensitivity. [PDF]

Sci Adv
Meng H, Chang Q, Zhang Y, Ren J, Guo H, Yu L, Qian C, Jiang Y, Zhang L, Cheng W.   +9 more
europepmc   +1 more source

Notch-1 suppressed vascular dementia via modulating AMPK/mTOR/TFEB/YAP signaling induced ferroptosis. [PDF]

Eur J Med Res
Zhu L, Wu Z, Zhang Z, Liu F, Zhang J, Qian X, Zheng Y.   +6 more
europepmc   +1 more source

Prognostic and predictive impact of NOTCH1 mutations in patients with chronic lymphocytic leukemia: a tertiary single-center experience. [PDF]

Front Oncol
D'Antiga M, Serafin A, Angotzi F, Cellini A, Bevilacqua A, Leone G, Danesin N, Cavarretta CA, Piazza F, Piovan E, Bonaldi L, Trentin L, Visentin A.   +12 more
europepmc   +1 more source

Genetic Landscape of Oral Carcinoma Cuniculatum and its Histological Mimics. [PDF]

Head Neck Pathol
Ono S, Fukawa Y, Hirose K, Hori Y, Motooka D, Harada H, Morii E, Toyosawa S, Ishimaru N, Yamamoto H.   +9 more
europepmc   +1 more source

The dual role of the Notch signaling pathway in digestive system cancers. [PDF]

Eur J Med Res
Xiang D, Wang T, Wei S, Zhao R, Li L, Lu J.   +5 more
europepmc   +1 more source

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Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Alleviate Diffuse Alveolar Hemorrhage Associated with Systemic Lupus Erythematosus in Mice by Promoting M2 Macrophage Polarization via the microRNA-146a-5p/NOTCH1 Axis

Immunological Investigations, 2022
Systemic lupus erythematosus (SLE)-associated diffuse alveolar hemorrhage (DAH) is a rare but extremely harmful condition. The current study sought to dissect the mechanisms underlying the effects of human umbilical cord mesenchymal stem cell (HUCMSC ...
Xun Chen, Chengli Su, Qing Wei, Hongmei Sun, Jun Xie, Guangmin Nong   +5 more
semanticscholar   +1 more source

Ubiquitination of Notch1 is regulated by MAML1-mediated p300 acetylation of Notch1

Biochemical and Biophysical Research Communications, 2011
Earlier studies demonstrated the involvement of the p300 histone acetyltransferase in Notch signaling but the precise mechanisms by which p300 might modulate Notch function remains to be investigated. In this study, we show that p300 acetylates Notch1 ICD in cell culture assay and in vitro, and conserved lysines located within the Notch C-terminal ...
Anita E, Popko-Scibor, Mikael J, Lindberg, Magnus L, Hansson, Teresa, Holmlund, Annika E, Wallberg   +4 more
openaire   +2 more sources