Results 291 to 300 of about 110,460 (323)
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Site-specific methylation of Notch1 controls the amplitude and duration of the Notch1 response
Science Signaling, 2015Methylation of the active Notch cleavage product promotes its degradation to produce short periods of Notch signaling necessary for proper development.
K. Hein +11 more
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Cancer Research
N6-methyladenosine (m6A) RNA modification is the most common and conserved epigenetic modification in mRNA and has been shown to play important roles in cancer biology.
Xinyue Zhang +12 more
semanticscholar +1 more source
N6-methyladenosine (m6A) RNA modification is the most common and conserved epigenetic modification in mRNA and has been shown to play important roles in cancer biology.
Xinyue Zhang +12 more
semanticscholar +1 more source
Cell Biology International, 2011
The Notch signalling pathway regulates proliferation, cell death and cell type specification that is critical for organogenesis. Mouse models carrying mutations in the Notch signalling pathway display defects in development of the placenta, suggesting that this pathway is required for placental development.
Didem Pelin, Sarikaya +1 more
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The Notch signalling pathway regulates proliferation, cell death and cell type specification that is critical for organogenesis. Mouse models carrying mutations in the Notch signalling pathway display defects in development of the placenta, suggesting that this pathway is required for placental development.
Didem Pelin, Sarikaya +1 more
openaire +2 more sources
Science, 2017
Cancer Mutations that activate Notch have been identified in several cancers. Weiland et al. find that Notch1 signaling within endothelial cells (ECs) promotes the invasion of distant organs by tumors. Abnormally high levels of active Notch1 are found in blood vessels associated with advanced human cancers.
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Cancer Mutations that activate Notch have been identified in several cancers. Weiland et al. find that Notch1 signaling within endothelial cells (ECs) promotes the invasion of distant organs by tumors. Abnormally high levels of active Notch1 are found in blood vessels associated with advanced human cancers.
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NOTCH1 modulates activity of DNA-PKcs
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2018DNA-dependent protein kinase catalytic subunit (DNA-PKcs) controls one of the most frequently used DNA repair pathways in a cell, the non-homologous end joining (NHEJ) pathway. However, the exact role of DNA-PKcs in NHEJ remains poorly defined. Here we show that NOTCH1 attenuates DNA-PKcs-mediated autophosphorylation, as well as the phosphorylation of ...
Adamowicz M +2 more
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p53 regulates thymic Notch1 activation
European Journal of Immunology, 2004AbstractNotch is crucial for multiple stages of T cell development, including the CD4+CD8+ double positive (DP)/CD8+ single positive (SP) transition, but regulation of Notchactivation is not well understood. p53 regulates Presenilin1 (PS1) expression, and PS1 cleaves Notch, releasing its intracellular domain (NIC), leading to the expression of ...
Amy M, Laws, Barbara A, Osborne
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Cardiovascular Research, 2019
AIMS Calcific aortic valve stenosis (CAVS) is the most common valvular heart disease, and is increased with elderly population. However, effective drug therapy has not been established yet.
Taku Toshima +19 more
semanticscholar +1 more source
AIMS Calcific aortic valve stenosis (CAVS) is the most common valvular heart disease, and is increased with elderly population. However, effective drug therapy has not been established yet.
Taku Toshima +19 more
semanticscholar +1 more source
Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia
Science, 2004A. Weng +8 more
semanticscholar +1 more source
Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis
Nature, 2007M. Hellström +16 more
semanticscholar +1 more source