Results 181 to 190 of about 16,426 (214)

Acetylation controls Notch3 stability and function in T-cell leukemia

Oncogene, 2011
Post-translational modifications of Notch3 and their functional role with respect to Notch3 overexpression in T-cell leukemia are still poorly understood. We identify here a specific novel property of Notch3 that is acetylated and deacetylated at lysines
Rocco Palermo, Saula Checquolo, M E Schininà   +2 more
exaly   +2 more sources

Notch3 Is Essential for Regulation of the Renal Vascular Tone

Hypertension, 2011
—The Notch3 receptor participates in the development and maturation of vessels. Mutations of Notch3 in humans are associated with defective regulation of cerebral blood flow.
Jean-Claude Dussaule, Sandrine Placier, Paul Milliez   +2 more
exaly   +2 more sources

Notch3 Is Critical for Proper Angiogenesis and Mural Cell Investment

Circulation Research, 2010
Rationale: The heterotypic interactions of endothelial cells and mural cells (smooth muscle cells or pericytes) are crucial for assembly, maturation, and subsequent function of blood vessels.
Wenbo Zhang, Ruth B Caldwell, Brenda Lilly   +2 more
exaly   +2 more sources

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Expression Profile of NOTCH3 in Mouse Spermatogonia

Cells Tissues Organs, 2017
Stable and sustainable spermatogenesis is supported by the strict regulation of self-renewal and differentiation of spermatogonial stem cells (SSC), which are a rare population of undifferentiated spermatogonia. It has been revealed that some signaling factors regulate the self-renewal of SSC; however, the molecular mechanism of SSC maintenance is ...
Ryu, Okada, Megumi, Fujimagari, Eri, Koya, Yoshikazu, Hirose, Tomomi, Sato, Yukio, Nishina   +5 more
openaire   +2 more sources

Evaluation of diagnostic NOTCH3 immunostaining in CADASIL

Acta Neuropathologica, 2003
CADASIL is caused by mutations in the NOTCH3 gene. Although increasingly recognized as a disease entity, the diagnostic confirmation can be lengthy or inconclusive. Recently, NOTCH3 immunostaining of skin biopsy specimens has been introduced as a new diagnostic test.
Saskia A J, Lesnik Oberstein, Sjoerd G, van Duinen, Rivka, van den Boom, Marion L C, Maat-Schieman, Mark A, van Buchem, Hans C, van Houwelingen, Ingrid M, Hegeman-Kleinn, Michel D, Ferrari, Martijn H, Breuning, Joost, Haan   +9 more
openaire   +2 more sources

CADASIL with a Novel NOTCH3 Mutation (Cys478Tyr)

Journal of Stroke and Cerebrovascular Diseases, 2015
Recently, an increasing number of NOTCH3 mutations have been described to cause cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Here, we report 2 CADASIL patients from a Japanese family, who were found to possess a novel NOTCH3 mutation.
Kokoro, Ozaki, Takashi, Irioka, Kinya, Ishikawa, Hidehiro, Mizusawa   +3 more
openaire   +2 more sources

Interpretation ofNOTCH3mutations in the diagnosis of CADASIL

Expert Review of Molecular Diagnostics, 2014
CADASIL is an autosomal dominant inherited disease, characterized by mid-adult onset of cerebrovascular disease and dementia. CADASIL is caused by mutations in the NOTCH3 gene, which encodes the NOTCH3 protein. Pathogenic mutations in CADASIL are highly distinctive in the sense that they lead to the loss or gain of a cysteine residue in 1 of the 34 ...
Rutten, J.W., Haan, J., Terwindt, G.M., Duinen, S.G. van, Boon, E.M.J., Oberstein, S.A.J.L.   +5 more
openaire   +3 more sources

Transendocytosis is impaired in CADASIL-mutant NOTCH3

Experimental Neurology, 2012
Mutations in the human NOTCH3 gene cause cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), but the pathogenesis of CADASIL has remained unclear. Recently, endocytosis of the Notch ectodermal domain into ligand-expressing cells, called transendocytosis, has come to be considered critical for Notch ...
Akiko, Watanabe-Hosomi, Yoshihisa, Watanabe, Masaki, Tanaka, Masanori, Nakagawa, Toshiki, Mizuno   +4 more
openaire   +2 more sources

การผลิตโมโนโคลนอลแอนติบอดีต่อเอคโตโดเมนของ Notch3

Notch3 เป็นโพรโทอองโคยีน (protooncogene) ซึ่งมีหน้าที่ควบคุมการเจริญ การแปรสภาพเพื่อทำหน้าที่เฉพาะและกระบวนการตายของเซลล์แบบอะพอพโทซีส ในระบบภูมิคุ้มกัน Notch3 ควบคุมการพัฒนาของ regulatory T cell และกระบวนการแปรสภาพเพื่อไปทำหน้าที่เฉพาะของ helper T cell ความผิดปกติของ Notch3 มีความสัมพันธ์กับการเกิดมะเร็งและโรคในระบบประสาท งานวิจัยนี้มีวัตถุประสงค์เพ ...
openaire   +1 more source

Notch3 and mitochondrial DNA

Journal of Molecular Medicine, 2001
Kazuo Ohashi, Frank Park, F.C. Luft
openaire   +2 more sources