Results 111 to 120 of about 2,529,587 (194)

Phenotypic variability in 446 CADASIL patients: Impact of NOTCH3 gene mutation location in addition to the effects of age, sex and vascular risk factors. [PDF]

J Cereb Blood Flow Metab, 2023
Dupé C, Guey S, Biard L, Dieng S, Lebenberg J, Grosset L, Alili N, Hervé D, Tournier-Lasserve E, Jouvent E, Chevret S, Chabriat H.   +11 more
europepmc   +1 more source

The epigenetic factor CTCF-L/BORIS regulates the NOTCH3 gene transcription in cancer cells

, 2013
Aberrant up-regulation of NOTCH3 gene plays a critical role in cancer pathogenesis. However, the underlying mechanisms are still unknown. We tested here the hypothesis that aberrant epigenetic modifications in the NOTCH3 promoter region might account for
SCREPANTI, Isabella, ZAMPIERI, Michele, CICCARONE, FABIO, C. Passananti, CAIAFA, Paola, TALORA, Claudio   +5 more
core  

The Role of Notch3 in Cancer

, 2018
The Notch family is a highly conserved gene group that regulates cell-cell interaction, embryogenesis, and tissue commitment. This review article focuses on the third Notch family subtype, Notch3.
Jason Whitt, Renata Jaskula-Stzul, Zviadi Aburjania, J. Bart Rose, Samuel Jang, Herbert Chen   +5 more
core   +1 more source

A randomized phase II trial of nab‐paclitaxel and gemcitabine with tarextumab or placebo in patients with untreated metastatic pancreatic cancer

Cancer Medicine, 2019
Purpose Notch signaling dysregulation is implicated in the development of pancreatic adenocarcinoma (PDAC). Tarextumab is a fully human IgG2 antibody that inhibits Notch2/3 receptors.
Zishuo Ian Hu, Johanna C. Bendell, Andrea Bullock, Noelle K. LoConte, Hassan Hatoum, Paul Ritch, Hugo Hool, Joseph W. Leach, James Sanchez, Davendra P. S. Sohal, John Strickler, Ravindranath Patel, Andrea Wang‐Gillam, Irfan Firdaus, Kenneth H. Yu, Ann M. Kapoun, Eric Holmgren, Lei Zhou, Jakob Dupont, Vincent Picozzi, Vaibhav Sahai, Eileen M. O'Reilly   +21 more
doaj   +1 more source

First report of a p.Cys484Tyr Notch3 mutation in a CADASIL patient with acute bilateral multiple subcortical infarcts—case report and brief review

BMC Neurology
Background CADASIL(Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy)is an inherited small vessel disease caused by mutations in NOTCH3 gene.
Weili Liu, Jie Zhang, Jian Li, Shuai Jia, Yanqiang Wang, Jianhong Geng, Yaozhen Wang   +6 more
doaj   +1 more source

A NOTCH3 transcriptional module induces cell motility in neuroblastoma

, 2013
Neuroblastoma is a childhood tumor of the peripheral sympathetic nervous system with an often lethal outcome due to metastatic disease. Migration and epithelial-mesenchymal transitions have been implicated in metastasis but they are hardly investigated ...
van Sluis, Peter, Versteeg, Rogier, van Groningen, Tim, Koster, Jan, van Nes, Johan, Chan, Alvin   +5 more
core   +1 more source

Colon stem cell characterization in normal and tumoral tissues: description of a novel feed-forward circuit of Msi-1 regulation [PDF]

, 2013
Normal tissues are organized in a hierarchical fashion, where rare somatic cells endowed with stem-like properties give origin to a population of differentiated cells forming the bulk of tissue.
Pastò, Anna
core  

Correlation Analysis of Rare NOTCH3 Gene Variants and Macrovascular Lesions

罕见病研究
ObjectiveCerebral autosomal dominant arteriopathy with subcortical infarcts and leukoen-cephalopathy (CADASIL) is caused by NOTCH3 gene variants and is predominantly characterized by cerebral small vessel disease.
WANG You, WANG Yingjie, YAO Ming, ZHU Yicheng   +3 more
doaj   +1 more source

Polymorphisms and mutational analysis of the NOTCH3 gene in a large cohort of patients affected by leukoencephalopathy

, 2008
Objective: The aim of the present study was to analyse the coding region and intron-exon boundaries of the NOTCH3 gene in a large cohort of patients af- fected by leukoencephalopathy to investigate the presence of genetic vari- ants. Patients and methods:
M Muglia, L Citrigno, A Magariello, FL Conforti, M Liguori, AL Gabriele, R Mazzei, P Servillo, C Ungaro, A Patitucci, T Sprovieri   +10 more
core  

Notch3 is essential for regulation of the renal vascular tone

, 2011
—The Notch3 receptor participates in the development and maturation of vessels. Mutations of Notch3 in humans are associated with defective regulation of cerebral blood flow.
Nada Boulos, Dominique Guerrot, Frank Helle, Sandrine Placier, Jean-claude Dussaule, Pierre Ronco, Anne Joutel, Christos Chatziantoniou, Paul Milliez, Sonja Djudjaj, Rine Placier, Jean-jacques Boffa   +11 more
core   +1 more source