Results 151 to 160 of about 136,068 (264)

Hypoxia inducible factor-1α-driven signaling networks regulating adult neurogenesis via Notch, Wnt, and MAPK pathways. [PDF]

Mol Biol Rep
Cornelio-Martínez S, Lagunas-Rangel FA.
europepmc   +1 more source

Adhesion‐Driven Removal of Microplastics From Aquatic Systems by Using Microgel Glues

Advanced Science, EarlyView.
Soft polymeric microgels function as “glues” that aggregate diverse microplastics through multivalent adhesion, promoting their interfacial deposition and co‐precipitation for efficient removal from water. Remarkably, this approach remains effective even for nanoscale plastic particles as small as 50 nm.
Jinmeng Zhang, Jie Xu, Wen Chen, Yanping Chen, Zixin Pan, Weitai Wu   +5 more
wiley   +1 more source

Notch signaling-targeted biomimetic hydrogel constructs an anti-inflammatory "flood-control" system to alleviate pyroptosis for intervertebral disc degeneration treatment. [PDF]

Mater Today Bio
Zhang R, Zhang X, Guo J, Yang Y, Niu J, Shen H, Zheng Y, Wang J, Wang S, Ni L, Yang H, Shi Q.   +11 more
europepmc   +1 more source

Topology‐Enriched Toughness Enhancement in Quasi‐Periodic Metastructures Featuring Tailorable Strong‐Weak Network

Advanced Science, EarlyView.
A quasi‐periodic Dart‐Kite (QDK) metastructure with a golden‐ratio‐constrained strong–weak bond network simultaneously enhances strength, toughness, and damage tolerance. Its distributed topology enables predictable, tailorable crack paths for precise fracture control and stable mechanics, demonstrating a high‐performance, controllable architecture ...
Tianyu Gao, Genda Wang, Jiabao Bai, Kai Liu   +3 more
wiley   +1 more source

Research and Simulation Analysis of Life Prediction in Notched Structures of DZ411 Alloy. [PDF]

Materials (Basel)
Liu Y, Wang W, Jiang X, Wei D, Wang Y.
europepmc   +1 more source

WTAP‐Mediated m6A Modification Targets the LRP1‐Lipid Metabolism Axis to Regulate Joint Cartilage Regeneration

Advanced Science, EarlyView.
WTAP drives cartilage regeneration by activating an LRP1‐dependent lipid metabolic program in macrophages, enhancing IL‐10 and TGF‐β secretion to promote chondrogenic differentiation. Leveraging this mechanism, virtual screening identifies LRP1‐targeting compounds that effectively stimulate cartilage repair, highlighting a druggable epigenetic ...
Chenyan Huang, Chenyu Deng, Zhengrong Gao, Chen Chen, Huimin Zheng, Yue Yang, Yan Wei   +6 more
wiley   +1 more source

3D epithelial cell topology tunes signaling range to promote precise patterning. [PDF]

Proc Natl Acad Sci U S A
Paci G, Berkemeier F, Baum B, Page KM, Mao Y.   +4 more
europepmc   +1 more source

Genetic Code Expanded T Cell for Controllable Immunotherapy

Advanced Science, EarlyView.
Our GCE‐CAR‐T cells enables tight, dose‐dependent, and function‐preserving control of CAR expression at the translational level through amber codon suppression and genetic incorporation of ncAA. ABSTRACT Chimeric antigen receptor (CAR)‐T cell therapy has demonstrated curative potential against hematologic malignancies, but its clinical application ...
Xue Wang, Yingao Gao, Yeyu Su, Yong Wang, Tao Liu   +4 more
wiley   +1 more source

AHNAK promotes oxidative stress and inflammatory responses in chronic obstructive pulmonary disease by activating the Notch pathway. [PDF]

J Thorac Dis
Zhang C, Liu Y.
europepmc   +1 more source

Natural Resistance to Ovarian Hyperstimulation Syndrome in Estrildid Finches Reveals Macrophage GPR183 as a Potential Therapeutic Target

Advanced Science, EarlyView.
Ovarian macrophage depletion reverses OHSS resistance in estrildid finches and exacerbates OHSS symptoms in rats. Activating macrophage GPR183 alleviates OHSS by reducing pro‐inflammatory factors, increasing immunomodulatory molecules, remodeling CD44/SDC4‐mediated communication, and restoring immune homeostasis.
Xiaofei Yan, Yongjie Huang, Jiabao Yang, Su Ma, Songsong Liu, Xuan Huang, Juergen Brosius, Huaping Zheng, Bing Yao, Li Chen, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source