Results 81 to 90 of about 336,762 (252)

Joint interpretation of AER/FGF and ZPA/SHH over time and space underlies hairy2 expression in the chick limb [PDF]

open access: yes, 2012
Embryo development requires precise orchestration of cell proliferation and differentiation in both time and space. A molecular clock operating through gene expression oscillations was first described in the presomitic mesoderm (PSM) underlying periodic ...
Andrade, Raquel P.   +2 more
core   +3 more sources

Inhibition of the Numb/Notch signaling pathway increases radiation sensitivity in human nasopharyngeal carcinoma cells

open access: yesKaohsiung Journal of Medical Sciences, 2019
Radiation therapy is the primary treatment for primary nasopharyngeal carcinoma (NPC). The aim of this study is to identify the effect of the Numb/Notch signaling pathway on radiation sensitivity in human NPC cells.
Er‐Dong Shen, Qiang Zeng
doaj   +1 more source

Delta-like Ligand-4-Notch Signaling Inhibition Regulates Pancreatic Islet Function and Insulin Secretion

open access: yesCell Reports, 2018
Although Notch signaling has been proposed as a therapeutic target for type-2 diabetes, liver steatosis, and atherosclerosis, its direct effect on pancreatic islets remains unknown.
Fabienne Billiard   +18 more
doaj   +1 more source

Finite element analysis of end notch flexure specimen [PDF]

open access: yes
A finite element analysis of the end notch flexure specimen for mode II interlaminar fracture toughness measurement was conducted. The effect of friction between the crack faces and large deflection on the evaluation of G sub IIc from this specimen were ...
Kochhar, N. K., Mall, S.
core   +1 more source

The Notch Pathway in Breast Cancer Progression

open access: yesThe Scientific World Journal, 2018
Objective. Notch signaling pathway is a vital parameter of the mammalian vascular system. In this review, the authors summarize the current knowledge about the impact of the Notch signaling pathway in breast cancer progression and the therapeutic role of
Emmanuel N. Kontomanolis   +6 more
doaj   +1 more source

Effect of Notch Depth on the Fatigue Damage of Notched FRP Plates.

open access: yesTRANSACTIONS OF THE JAPAN SOCIETY OF MECHANICAL ENGINEERS Series A, 1994
A fatigue failure criterion based on the concept of linear notch mechanics for predicting the fatigue life of notched FRP plates is subjected to further experimental scrutiny. An experimental program is presented which examines the effect of notch depth on the fatigue failure of notched FRP plates. This is accomplished by obtaining experimental data on
Hiizu Hyakutake, Toshihiro Yamamoto
openaire   +2 more sources

Effect of Repeated Loads on the Low Temperature Fracture Behavior of Notched and Welded Plates [PDF]

open access: yes, 1967
The influence of repeated loadings on the susceptibility of weldments to fracture in a brittle manner is studied for an ABS-Class C steel. The test members have consisted primarily of 12, 24 and 36 in.
Cannon, J.P., Kiefner, J.F., Munse, W.H.
core  

Alterations in the Notch4 pathway in cerebral endothelial cells by the HIV aspartyl protease inhibitor, nelfinavir

open access: yesBMC Neuroscience, 2008
Background Aspartyl protease inhibitors (PIs) used to treat HIV belong to an important group of drugs that influence significantly endothelial cell functioning and angiogenic capacity, although specific mechanisms are poorly understood.
Chao Ying   +4 more
doaj   +1 more source

Modelling acid attack of oilwell cement exposed to carbonated brine: effect of specimen geometry on experimental results [PDF]

open access: yes, 2019
In recent years, the authors and co-workers have developed a diffusion-reaction model for the degradation process of oilwell cements exposed to carbonated brines in the context of CO2 capture and storage in abandoned oil reservoirs.
Barandiarán Villegas, Lucía Belén   +3 more
core   +1 more source

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