Results 71 to 80 of about 136,068 (264)

Inhibition of the Numb/Notch signaling pathway increases radiation sensitivity in human nasopharyngeal carcinoma cells

open access: yesKaohsiung Journal of Medical Sciences, 2019
Radiation therapy is the primary treatment for primary nasopharyngeal carcinoma (NPC). The aim of this study is to identify the effect of the Numb/Notch signaling pathway on radiation sensitivity in human NPC cells.
Er‐Dong Shen, Qiang Zeng
doaj   +1 more source

From Shear to Sound: Mechanics–Acoustics Mapping of TPMS Lattices

open access: yesAdvanced Engineering Materials, EarlyView.
Triply periodic minimal surface (TPMS) lattices are mapped across mechanical and acoustic performance, revealing that descriptors validated in compression fail under shear. First‐time comparison with trusses included. A transition from porous to resonance‐driven absorption emerges at 25% density.
Lucía Doyle   +3 more
wiley   +1 more source

A examination of notch effects in the fatigue of carbon steel by linear notch mechanics.

open access: yesTRANSACTIONS OF THE JAPAN SOCIETY OF MECHANICAL ENGINEERS Series A, 1988
Fatigue tests of 0.31% carbon steel specimens with a circumferential groove were made in a wide range of configuration parameters. As a result, it has been confirmed that the linear notch mechanics (LNM) can be successfully applied to the examination of notch effects in fatigue.
NISITANI, Hironobu   +3 more
openaire   +2 more sources

A Dislocation Perspective on Strength and Toughness in Ceramics

open access: yesAdvanced Engineering Materials, EarlyView.
Dislocations in ceramics enjoy a long but yet under‐appreciated history. The three research waves for dislocations in ceramics highlight the topic evolution over the last 90 years. This review focuses on the impact of dislocation on strength and toughness in ceramics.
Xufei Fang
wiley   +1 more source

Delta-like Ligand-4-Notch Signaling Inhibition Regulates Pancreatic Islet Function and Insulin Secretion

open access: yesCell Reports, 2018
Although Notch signaling has been proposed as a therapeutic target for type-2 diabetes, liver steatosis, and atherosclerosis, its direct effect on pancreatic islets remains unknown.
Fabienne Billiard   +18 more
doaj   +1 more source

Grain Refinement During Severe Plastic Deformation and Similitude of Subgrain Formation: A Molecular Dynamics Study

open access: yesAdvanced Engineering Materials, EarlyView.
Molecular dynamics is used to investigate structure refinement during severe plastic deformation. The results show similitude with experimental data. Molecular dynamics simulations of severe plastic deformation of monocrystalline and polycrystalline samples by multiaxial compression of aluminum are carried out.
Roberto B. Figueiredo
wiley   +1 more source

Effect of Notch-Root Radius on Fatigue Damage of Notched FRP Plates.

open access: yesJournal of the Society of Materials Science, Japan, 1993
Fatigue tests under plane bending and pulsating tension were carried out the notched FRP plates for a wide range of notch-root radii and stress amplitudes. An attention was focussed on the fatigue damage development near the notch root of specimens. The luminance at the limited spot near the notch root was measured successively during fatigue tests to ...
HYAKUTAKE, Hiizu, YAMAMOTO, Toshihiro
openaire   +2 more sources

Advanced Electron Microscopy and Microcomputed Tomography Analysis of Single‐Crystal Ni‐Base Superalloys After Short‐Term Multiaxial Creep

open access: yesAdvanced Engineering Materials, EarlyView.
This work studies the anisotropic behavior of circular notched tensile specimens of Ni‐base superalloy single crystals during high‐temperature tensile creep along [001], [110], and [111]. Correlative scale‐bridging imaging of specimens reveals early rupture along [110] because 1) plastic deformation proceeds faster at notch center; 2) more (brittle ...
Leonardo Agudo Jácome   +6 more
wiley   +1 more source

Design of a UWB Interference-Rejection LNA Based on a Q-Enhanced Notch Filter

open access: yesMicromachines
A Q-enhanced notch filter for interference-rejection LNAs is proposed in this brief. The active capacitance is introduced into the notch filter to improve the quality factor by the negative resistance effect.
Jiaxuan Li, Yuxin Fan, Fan Meng
doaj   +1 more source

The Notch Pathway in Breast Cancer Progression

open access: yesThe Scientific World Journal, 2018
Objective. Notch signaling pathway is a vital parameter of the mammalian vascular system. In this review, the authors summarize the current knowledge about the impact of the Notch signaling pathway in breast cancer progression and the therapeutic role of
Emmanuel N. Kontomanolis   +6 more
doaj   +1 more source

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