Results 71 to 80 of about 9,549,485 (300)

Converting melanoma-associated fibroblasts into a tumor-suppressive phenotype by increasing intracellular Notch1 pathway activity.

PLoS ONE, 2021
Cancer-associated fibroblasts (CAFs) play a crucial role in cancer progression, drug resistance and tumor recurrence. We have recently shown that the Notch pathway determines the tumor-regulatory role of experimentally created 'CAFs'.
Hongwei Shao, Mecker Moller, Long Cai, Rochelle Prokupets, Cuixia Yang, Connor Costa, Kerstin Yu, Nga Le, Zhao-Jun Liu   +8 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Drosophila Cyclin G Is a Regulator of the Notch Signalling Pathway during Wing Development. [PDF]

PLoS ONE, 2016
Notch signalling regulates a multitude of differentiation processes during Drosophila development. For example, Notch activity is required for proper wing vein differentiation which is hampered in mutants of either the receptor Notch, the ligand Delta or
Anja C Nagel, Jutta Szawinski, Mirjam Zimmermann, Anette Preiss   +3 more
doaj   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Influence of notch hole wall defects on crack propagation under notch blasting

Baozha yu Chongji
The defective cracks were prefabricated on the wall of the notch holes by using polymethyl methacrylate (PMMA) material, which were parallel or vertical to the notch, and the distance from the defective cracks to the hole center was 2, 3, and 4 mm.
Yuhang CHENG, Feng LIU, Wei DAI, Zhengde ZHU, Rujie BI, Changxin PAN   +5 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Study on the Influence of Notched Empty Hole Parameters on Directional Fracture Blasting Effect

Buildings
Placing empty holes between charging holes is widely used in blasting engineering to achieve directional fracture blasting. Studies have shown that the presence of a notch along the empty hole wall enhances stress concentration and supports improved ...
Xiantang Zhang, Rongyan Ma, Yong Yang, Tonghua Fu, Yubing Tian, Haibo Yan, Deqing Wang, Xiangtuan Jiao, Hongmin Zhou   +8 more
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Experimental Study on the Effect of Offset Notch on Fracture Properties of Rock under Three-Point Bending Beam

Advances in Materials Science and Engineering, 2020
To investigate the effects of offset notch on the fracture properties of rock beam under bending load, granite beam specimens with “one single offset notch” and “central and offset double notches” are made.
Qifeng Guo, Xinghui Wu, Meifeng Cai, Shengjun Miao   +3 more
doaj   +1 more source

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source