Results 91 to 100 of about 133,611 (360)
Interaction between Notch signaling pathway and bioactive compounds and its intervention on cancer
Frontiers in NutritionThe Notch signaling pathway is pivotal in cancer regulation, with its effects varying based on activation degree, tissue origin, and microenvironment. The dual role of Notch signaling is significant. It can promote or inhibit cancer progression depending
Rong-Zu Nie +13 more
doaj +1 more source
The Retinal Pigment Epithelium Is a Notch Signaling Niche in the Mouse Retina
Cell Reports, 2017 Summary: Notch signaling in neural progenitor cell is triggered by ligands expressed in adjacent cells. To identify the sources of active Notch ligands in the mouse retina, we negatively regulated Notch ligand activity in various neighbors of retinal ...
Taejeong Ha +8 more
doaj +1 more source
Karl Popper and the Mechanisms of Hydrogen Embrittlement
Advanced Engineering Materials, EarlyView.Representation of the beginning of loss of ductility rather than embrittlement. Small concentrations of hydrogen in a diffusible form within iron are well‐established to harm the mechanical integrity of steels. There are theories that attempt to explain the pernicious role of hydrogen.
H. K. D. H. Bhadeshia
wiley +1 more source
Notch Signaling in Breast Cancer: A Role in Drug Resistance
, 2020 Breast cancer is a heterogeneous disease that can be subdivided into unique molecular subtypes based on protein expression of the Estrogen Receptor, Progesterone Receptor, and/or the Human Epidermal Growth Factor Receptor 2.
McKenna BeLow, Clodia Osipo
core +1 more source
Spatiotemporal oscillations of Notch1, Dll1 and NICD are coordinated across the mouse PSM [PDF]
, 2014 During somitogenesis, epithelial somites form from the pre-somitic mesoderm (PSM) in a periodic manner. This periodicity is regulated by a molecular oscillator, known as the 'segmentation clock', that is characterised by an oscillatory pattern of gene ...
Dale, J. Kim +7 more
core +1 more source
"Notch-Off": a perspective on the termination of Notch signalling
The International Journal of Developmental Biology, 2009 During Notch mediated lateral inhibition, interacting cells establish or amplify differences in Notch signalling, which are then translated into distinct cell fate decisions according to the developmental context. In recent years, several mechanisms that increase the signalling capacity of interacting cells have been uncovered (reviewed in Bray, 2006 ...
Rita, Fior, Domingos, Henrique
openaire +3 more sources
Notch Signaling in Development and Cancer [PDF]
Endocrine Reviews, 2007 Notch is an evolutionarily conserved local cell signaling mechanism that participates in a variety of cellular processes: cell fate specification, differentiation, proliferation, apoptosis, adhesion, epithelial-mesenchymal transition, migration, and angiogenesis. These processes can be subverted in Notch-mediated pathological situations.
Victoria, Bolós +2 more
openaire +2 more sources
Fatigue Crack Initiation and Growth in Nanocrystalline Ni at Multiple Length‐Scales
Advanced Engineering Materials, EarlyView.Overview of miniaturized in situ SEM fatigue setup and resultant fatigue crack growth data for nanocrystalline Ni. The presented study focuses on the analysis of fatigue crack growth rate (FCGR) in focused ion beam‐notched microcantilevers prepared from nanocrystalline (NC) Ni as a model material.
Igor Moravcik +7 more
wiley +1 more source
Activation of the Notch signaling pathway promotes neurovascular repair after traumatic brain injury
Neural Regeneration Research, 2015 The Notch signaling pathway plays a key role in angiogenesis and endothelial cell formation, but it remains unclear whether it is involved in vascular repair by endothelial progenitor cells after traumatic brain injury.
Qi-shan Ran +3 more
doaj +1 more source
Involvement of notch signaling in wound healing. [PDF]
PLoS ONE, 2007 The Notch signaling pathway is critically involved in cell fate decisions during development of many tissues and organs. In the present study we employed in vivo and cell culture models to elucidate the role of Notch signaling in wound healing.
Srinivasulu Chigurupati +14 more
doaj +1 more source