Results 91 to 100 of about 155,910 (299)
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Role of Notch Signaling Pathway in Glioblastoma Pathogenesis [PDF]
Cancers, 2019 Notch signaling is an evolutionarily conserved pathway that regulates important biological processes, such as cell proliferation, apoptosis, migration, self-renewal, and differentiation. In mammals, Notch signaling is composed of four receptors (Notch1–4) and five ligands (Dll1-3–4, Jagged1–2) that mainly contribute to the development and maintenance ...
Riccardo Bazzoni, Angela Bentivegna
openaire +2 more sources
Promotion of proliferation and metastasis of hepatocellular carcinoma by LncRNA00673 based on the targeted-regulation of notch signaling pathway [PDF]
, 2017 we read with great interest the paper by Dr. Chen et al1, recently published in European Review for Medical and Pharmacological Sciences and titled ‘‘Promotion of proliferation and metastasis of hepatocellular carcinoma by LncRNA00673 based on the ...
Assirati G +7 more
core
Biomaterial-based ligand presentation to induce notch signaling in vitro [PDF]
, 2013 T cell adoptive transfer is an important procedure in immunotherapy. In immunocompromised patients, T cells may need to be developed from stem cells, requiring the induction of Notch signaling events responsible for native T cell differentiation in the ...
Mehta, Naveen
core +1 more source
FEBS Open Bio, EarlyView.Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu +10 more
wiley +1 more source
Effect of radiation on the Notch signaling pathway in osteoblasts
International Journal of Molecular Medicine, 2013 Notch signaling has been shown to be important in osteoblast differentiation. Therapeutic radiation has been shown to alter the skeletal system, yet little information is available on the changes in Notch signaling in irradiated osteoblasts.
Yang, Bing +8 more
openaire +3 more sources
From the Notch Signaling Pathway to Ribosome Biogenesis [PDF]
Plant Signaling & Behavior, 2007 Nearly 240 WD repeat proteins have been identified from the Arabidopsis genome. Among these, some well characterized WDR proteins were shown to regulate various developmental processes in plants.1 We have recently isolated in Solanum chacoense a homolog of the Drosophila NOTCHLESS gene.
Sier-Ching, Chantha +2 more
openaire +2 more sources
European Journal of Inflammation, 2023 Objectives: The Notch signaling pathway serves as the key regulator of the biological functions of macrophages and may affect the role of macrophages in the development of pigeon breeder’s lung (PBL).
Wenyi Wang +7 more
doaj +1 more source
Implications of Notch Signaling in Taste Cell Replacement [PDF]
, 2017 Cyclophosphamide (CYP) was one of the first chemotherapy drugs developed and used to treat several types of cancer, by disrupting proliferative cells. Unfortunately, CYP is unable to differentiate between cancerous cells and healthy cells turning over ...
D\u27Alessandro, Nicholas B
core +1 more source
Dnmt3b ablation impairs fracture repair through upregulation of Notch pathway [PDF]
, 2020 We previously established that DNA methyltransferase 3b (Dnmt3b) is the sole Dnmt responsive to fracture repair and that Dnmt3b expression is induced in progenitor cells during fracture repair.
Abu-Amer, Yousef +8 more
core +1 more source