Results 151 to 160 of about 93,970 (258)

Establishing Sensory Neurons as Therapeutic Targets in Peripheral Neuropathy Driven by Polyglutamine Expanded Murine ATXN3

Annals of Neurology, EarlyView.
Repeat expansion disorders frequently involve peripheral neuropathy, yet mechanisms remain unclear. Using a spinocerebellar ataxia type 3 (SCA3) Knock‐In Atxn3Q300/Q6, we identify progressive sensorimotor deficits, peripheral nerve pathology, and dorsal root ganglia RNA splicing dysregulation.
Juan P. Mato, John M. Hayes, Jacen Emerson, Maeha Sridharan, Toluwani Adelaja, Arsal Naeem, Alexandra F. Putka, Hayley S. McLoughlin   +7 more
wiley   +1 more source

Interaction between Notch signaling pathway and bioactive compounds and its intervention on cancer. [PDF]

Front Nutr
Nie RZ, Wang H, Wang SS, Luo HM, Chen C, Jing ZH, Li PF.   +6 more
europepmc   +1 more source

Proto‐Panic Modulation by Caffeine‐Proteinoid Complexes

Journal of Applied Polymer Science, EarlyView.
Caffeine–proteinoid microspheres synthesized by thermal polymerization exhibit compartmentalized drug loading with encapsulation efficiencies of 61%–82% and triphasic release kinetics. Electrochemical monitoring reveals multi‐scale oscillatory dynamics consistent with chaotic and damped harmonic behavior, while Boolean logic operations demonstrate ...
Panagiotis Mougkogiannis, Andrew Adamatzky   +1 more
wiley   +1 more source

LECT2 promotes liver regeneration across developmental stages by activating the ADAM10-NOTCH signaling pathway. [PDF]

Hepatol Commun
Zhang H, Wang W, Gao Y, Qian Y, Xu W, Yin H, Qiu Q, Zhang L, Zhu S, Li X, Wu Z, Zuo L, Wang J, Tang H, Hu H, Wei Y, Xu F, Chen J, Cao F, Xu H.   +19 more
europepmc   +1 more source

An unusual titanosaur axis from the Upper Cretaceous of Brazil and its significance for sauropod anatomy and systematics

The Anatomical Record, EarlyView.
Abstract The Upper Cretaceous São José do Rio Preto Formation (Bauru Group, southeastern Brazil) has yielded a fragmentary but taxonomically diverse record of titanosaur sauropods, although elements from cervical series remain scarce. Here, we describe a nearly complete sauropod axis from the Vila Ventura Paleontological Area, representing an uncommon ...
Bruno A. Navarro, Jeffrey A. Wilson Mantilla, Jhonata H. A. Martins, Fabiano V. Iori, Leonardo S. Paschoa, Alberto B. Carvalho, Joseli M. Piranha, Hussam Zaher   +7 more
wiley   +1 more source

Targeting the Notch signaling pathway: molecular mechanisms and therapeutic strategies for cardiac repair after myocardial infarction. [PDF]

Front Cardiovasc Med
Zhang Z, Xie F, Cheng J, Liu X, Wang X, Long J, Feng Q, Yuan D.   +7 more
europepmc   +1 more source

Nasal soft‐tissue anatomy of Triceratops and other horned dinosaurs

The Anatomical Record, EarlyView.
Abstract Although ceratopsid dinosaurs possess a characteristically hypertrophied narial region, soft‐tissue anatomy associated with such a skeletal structure and their biological significance remain poorly understood. The present study provides the first comprehensive hypothesis on the soft‐tissue anatomy in the ceratopsid rostrum based on the Extant ...
Seishiro Tada, Takanobu Tsuihiji, Hiroki Ishikawa, Noriyuki Wakimizu, Soichiro Kawabe, Kodai Sakane   +5 more
wiley   +1 more source

Notch Signaling Pathway Regulates Ozone-Induced Lung Circadian Rhythm Disruption. [PDF]

Toxics
Zhang X, Jian X, Miao X, Jia Y.
europepmc   +1 more source

Pelvic morphology and body size in relation to the preauricular sulcus: Evidence from medieval to modern Iberia

The Anatomical Record, EarlyView.
Abstract The preauricular sulcus has long been debated as a pelvic feature variably attributed to obstetric stress, ligamentous traction, and broader biomechanical processes. To clarify its determinants, we analyzed 409 adult individuals from three archeological and one early modern skeletal collection from the Iberian Peninsula, integrating graded ...
Rebeca García‐González, Julia Muñoz‐Guarinos, Nico Cirotto, Sonia Díaz‐Navarro, Laura Rodríguez, José Miguel Carretero   +5 more
wiley   +1 more source

Regulation of microglial polarization via notch signaling pathway by intrathecal administration of tanshinone IIA-PLGA sustained-release microspheres to promote neurological recovery after spinal cord injury. [PDF]

Front Bioeng Biotechnol
Li C, Xu L, Jiang G, Yang K, Zhong W, Cao Z, Wang X, Yang Y, Yu X.   +8 more
europepmc   +1 more source