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Notch Signaling Pathway and Cancer Metastasis
2012Cancer metastasis is the leading cause of cancer-related deaths all over the world at present. Accumulated researches have demonstrated that cancer metastasis is composed of a series of successive incidents, mainly including epithelial-mesenchymal transition (EMT), malignant cell migration, resistance to anoikis, and angiogenesis and lymphangiogenesis ...
Yi-Yang, Hu +4 more
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Notch Signaling Pathway in Ovarian Cancer
International Journal of Gynecological Cancer, 2009The literature is replete with reports of the paradoxical role of Notch signaling in human cancer. Notch appears to act as both an oncogene and a tumor suppressor gene depending on the cellular context. This review focuses on the nascent knowledge of Notch signaling in ovarian cancer. Despite advances in chemotherapy and radical surgery, ovarian cancer
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Notch Signaling Pathway in Carcinogenesis
2018The Notch signaling pathway is a highly conserved pathway in most multicellular organisms. It is of critical importance for cell proliferation, differentiation, and homeostasis. Aberrant Notch signaling can give rise to a number of pathologies including cancer.
Andrei Zlobin +3 more
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An overview of the Notch signalling pathway
Seminars in Cell & Developmental Biology, 2003The Notch receptor plays a key role in modulating cell fate decisions throughout the development of invertebrate and vertebrate species. Four Notch homologues have been identified in the human genome and aberrant Notch function has been associated with a number of human diseases.
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Modulating Notch signaling by pathway-intrinsic and pathway-extrinsic mechanisms
Current Opinion in Genetics & Development, 2008Despite a relatively simple core-signaling transduction machinery, Notch signaling controls cell differentiation in many different tissues and at multiple stages in a given cell lineage. To understand how Notch generates this multitude of cellular responses, it is important to learn how the Notch-signaling output is modulated at various levels. Pathway-
Lorenz, Poellinger, Urban, Lendahl
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Targeting the Notch signaling pathway in autoimmune diseases
Expert Opinion on Therapeutic Targets, 2010The Notch signaling pathway regulates a variety of processes and has been linked to diverse effects. Aberrant Notch function is important in several disorders. Pre-clinical studies have suggested that inhibition of Notch is an attractive approach to treat hematologic and solid malignancies.
Daoxin, Ma +3 more
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Notch signalling pathway and human diseases
Journal of Hepatology, 2000Notch-l mutation (TAN-l) and T-cell lymphoblastic leukaemia Mutation of the human Notch1 was identified through the observation of a chromosomal translocation t(7;9) from tumour cells of three cases of human T lymphoblastic leukaemia. The breakpoint occurs within 100 bp of an intron of Notchl.
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Notch 1 signaling pathway effect on implantation competency
Fertility and Sterility, 2011To investigate the relationship between the Notch 1 signaling pathway and the embryo implantation rate.Mouse embryos were cultured in vitro, and implantation competency was quantified.Tertiary fertility center of a university teaching hospital.Outbred ICR strain mouse embryos.The expression of Notch 1 was altered by adding a γ-secretase inhibitor to ...
Po-Wei, Chu +4 more
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Wnt and Notch signaling pathways selectively regulating hematopoiesis
Annals of Hematology, 2010Hematopoietic stem and progenitor cells (HSPCs) are the source of all blood cells in the adult body. The pool of HSPCs is formed during embryogenesis process through a well-characterized succession of intra-embryonic regions and organs. The spatial and temporal restrictions in definitive hematopoietic development and the signaling molecules involved ...
Kun, Zhou +6 more
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