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Notch signalling pathway and human diseases
Seminars in Cell & Developmental Biology, 1998Several homologs of the Drosophila Notch receptor and its ligands, Delta/Serrate, have been cloned in man. Three human disorders including a neoplasia (a T-cell acute lymphoblastic leukemia/lymphoma), a late onset neurological disease (CADASIL) and a developmental disorder (the Alagille syndrome) are associated with mutations in, respectively, the ...
A, Joutel, E, Tournier-Lasserve
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An overview of the Notch signalling pathway
Seminars in Cell & Developmental Biology, 2003The Notch receptor plays a key role in modulating cell fate decisions throughout the development of invertebrate and vertebrate species. Four Notch homologues have been identified in the human genome and aberrant Notch function has been associated with a number of human diseases.
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Advances in Understanding the Notch Signaling Pathway in the Cochlea
Current Pharmaceutical Design, 2023Abstract: The cochlear structure is highly complex and specific, and its development is regulated by multiple signaling pathways. Abnormalities in cochlear development can lead to different degrees of loss of function. Hair cells (HCs), which are difficult to regenerate in the mature mammalian cochlea, are susceptible to damage from noise and ototoxic
Xiaoying Chen +4 more
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Notch Signaling Pathway in Ovarian Cancer
International Journal of Gynecological Cancer, 2009The literature is replete with reports of the paradoxical role of Notch signaling in human cancer. Notch appears to act as both an oncogene and a tumor suppressor gene depending on the cellular context. This review focuses on the nascent knowledge of Notch signaling in ovarian cancer. Despite advances in chemotherapy and radical surgery, ovarian cancer
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Notch in the pathway: The roles of Notch signaling in neural crest development
Seminars in Cell & Developmental Biology, 2005Here, we review recent studies that suggest that Notch signaling has two roles during neural crest development: first in establishing the neural crest domain within the ectoderm via lateral induction and subsequently in diversifying the fates of cells that arise from the neural crest via lateral inhibition.
Robert A, Cornell, Judith S, Eisen
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Roles of the Notch Signaling Pathway in Ovarian Functioning
Reproductive Sciences, 2021The Notch signaling pathway regulates cell invasion, adhesion, proliferation, apoptosis, and differentiation via cell-to-cell interactions and plays important physiological roles in the ovary. This review summarizes current knowledge about the Notch signaling pathway in relation to ovarian functions and reveals the potential underlying mechanisms.
Shuhan Guo, Song Quan, Siyi Zou
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SEPT4 is regulated by the Notch signaling pathway
Molecular Biology Reports, 2011Notch receptor-mediated signaling is an evolutionarily conserved pathway that regulates diverse developmental processes and its dysregulation has been implicated in a variety of developmental disorders and cancers. Notch functions in these processes by activating expression of its target genes.
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Roles of the Notch signaling pathway and microglia in autism
Behavioural Brain Research, 2023The Notch signaling pathway is mainly involved in the regulation of neural stem cell proliferation, survival and differentiation during the development of the central nervous system. As a neurodevelopmental disorder, autism is associated with an abnormal increase in the number of microglia in several brain regions.
Ying-Hua, Zhang +4 more
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Role of the Notch signalling pathway in tooth morphogenesis
Archives of Oral Biology, 2005Notch receptors are involved in cell fate decisions through the process of lateral inhibition or inductive signalling. Jagged2 belongs to the family of transmembrane proteins that serve as the ligands for Notch receptors. We have analysed the expression of the Jagged2 gene in developing mouse teeth.
Mitsiadis, T A, Regaudiat, L, Gridley, T
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Notch Signaling Pathway and Cancer Metastasis
2012Cancer metastasis is the leading cause of cancer-related deaths all over the world at present. Accumulated researches have demonstrated that cancer metastasis is composed of a series of successive incidents, mainly including epithelial-mesenchymal transition (EMT), malignant cell migration, resistance to anoikis, and angiogenesis and lymphangiogenesis ...
Yi-Yang, Hu +4 more
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