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Targeting the Notch signaling pathway in autoimmune diseases
Expert Opinion on Therapeutic Targets, 2010The Notch signaling pathway regulates a variety of processes and has been linked to diverse effects. Aberrant Notch function is important in several disorders. Pre-clinical studies have suggested that inhibition of Notch is an attractive approach to treat hematologic and solid malignancies.
Daoxin, Ma +3 more
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Notch Signalling Pathways and Their Importance in the Treatment of Cancers
Current Drug Targets, 2018The Notch pathway is an evolutionarily conserved, intercellular signalling system which is present in all multicellular organisms and mammals. The Notch pathway plays an important role in the embryonic development as it controls cell proliferation, cell differentiation and binary cell fate decisions.In the present review, we highlight the Notch ...
Seong Lin, Teoh, Srijit, Das
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The Notch and Sonic hedgehog signalling pathways in immunity
Molecular Immunology, 2004There is an increasing body of knowledge demonstrating that genes involved in cell fate decisions during development also play a role in the continuous cell fate decisions made by the mature immune system in response to foreign antigen. This review concentrates on the role of the Notch and Sonic hedgehog (Shh) signalling pathways in the development and
Robert A, Benson +3 more
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Notch Signaling Pathway in Carcinogenesis
2018The Notch signaling pathway is a highly conserved pathway in most multicellular organisms. It is of critical importance for cell proliferation, differentiation, and homeostasis. Aberrant Notch signaling can give rise to a number of pathologies including cancer.
Andrei Zlobin +3 more
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The Notch Signalling Pathway in the Development of the Mouse Placenta
Placenta, 2008Notch signalling is an evolutionarily conserved pathway taking part in many developmental and cell type specification processes. The development of a functional mouse placenta is a dynamic phenomenon involving a number of different processes: trophoblast cell type specification, branching of the chorion and fetal vascular morphogenesis, as well as ...
Gasperowicz, Malgorzata, Otto, Florian
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Conservation of the Notch signalling pathway in mammalian neurogenesis
Development, 1997ABSTRACT The Notch pathway functions in multiple cell fate determination processes in invertebrate embryos, including the decision between the neuroblast and epidermoblast lineages in Drosophila. In the mouse, targeted mutation of the Notch pathway genes Notch1 and RBP-Jk has demonstrated a role for these genes in somite segmentation ...
J L, de la Pompa +10 more
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Notch signalling: a simple pathway becomes complex
Nature Reviews Molecular Cell Biology, 2006A small number of signalling pathways are used iteratively to regulate cell fates, cell proliferation and cell death in development. Notch is the receptor in one such pathway, and is unusual in that most of its ligands are also transmembrane proteins; therefore signalling is restricted to neighbouring cells.
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Modulation of VEGF signalling output by the Notch pathway
BioEssays, 2008AbstractThe formation of blood vessels within the vascular system entails a variety of cellular processes, including proliferation, migration and differentiation. In many cases, these diverse processes need to be finely coordinated among neighbouring endothelial cells in order to establish a functional vascular network.
Arndt F, Siekmann +2 more
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Modulating Notch signaling by pathway-intrinsic and pathway-extrinsic mechanisms
Current Opinion in Genetics & Development, 2008Despite a relatively simple core-signaling transduction machinery, Notch signaling controls cell differentiation in many different tissues and at multiple stages in a given cell lineage. To understand how Notch generates this multitude of cellular responses, it is important to learn how the Notch-signaling output is modulated at various levels. Pathway-
Lorenz, Poellinger, Urban, Lendahl
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