Results 51 to 60 of about 26,639 (292)

Notch Effect on Plastic Deformation of Metallic Glass: A Numerical Study by Revised Free-Volume Theory

open access: yesAdvances in Materials Science and Engineering, 2020
By means of a revised free-volume theory, the notch effect on metallic glass was systematically investigated by the numerical method. Simulations on specimens without notches demonstrated that the parameters being determined in this work could reasonably
J. F. Yan   +4 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Notches [PDF]

open access: yes
Economists have an instinctively negative reaction to any government program that creates a "notch," that is, a discontinuity in a budget constraint. For example, welfare programs like public housing are structured so that a finite lump of benefits is ...
Harvey S. Rosen, Alan S. Blinder
core   +1 more source

Experimental Study of Free-Convection from Rectangular Fins Array on a Heated Horizontal Plate with Notch Effects

open access: yesمجلة النهرين للعلوم الهندسية, 2017
In this work , experimental investigation has been done for free-convection heat transfer from rectangular fins array on a heated horizontal base plate to surrounding air in the steady-state flow  condition  with  rectangular notch portion effects.
Saad Najeeb Shehab
doaj  

Experimental Study of Forced- Convection from Horizontal Rectangular Fins Array into Air Duct

open access: yesAl-Khawarizmi Engineering Journal, 2019
In this work, an experimental study has been done to expect the heat characteristics and performance of the forced-convection from a heated horizontal rectangular fins array to air inside a rectangular cross-section duct.
Saad Najeeb Shehab
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

The prevalence of audiometric notches in adolescents in Germany: The Ohrkan-study

open access: yesNoise and Health, 2013
Although there is concern about increasing hearing loss in adolescents caused by leisure noise exposure, prevalence data are scarce. In an US study, about 16-17% of adolescents were affected by audiometric notches.
Dorothee Twardella   +5 more
doaj   +1 more source

Notch one for activating NOTCH [PDF]

open access: yesScience-Business eXchange, 2011
Vanderbilt researchers have identified downregulation of NOTCH signaling as a mechanism tumors use to evade the immune system, suggesting that restoring activation of the pathway could improve cancer immunotherapy. Researchers have been split on whether it is better to up- or downregulate NOTCH.
openaire   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

open access: yesMolecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Coastal dune dynamics in response to excavated foredune notches [PDF]

open access: yes, 2018
Dune management along developed coasts has traditionally focussed on the suppression of the geomorphic dynamics of the foredune to improve its role in sea defence.
Arens, S. M.   +3 more
core   +3 more sources

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