Results 51 to 60 of about 23,253 (298)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
International Journal of Ceramic Engineering & ScienceThis study utilizes finite element analysis (FEA) to explore the effect of standardized notch shapes—triangular, circular, and rectangular on the tensile behavior of oxide–oxide (O–O) ceramic matrix composites (CMCs) across various temperature ranges ...
Karthikeyan Ramachandran +2 more
doaj +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Coastal dune dynamics in response to excavated foredune notches [PDF]
, 2018 Dune management along developed coasts has traditionally focussed on the suppression of the geomorphic dynamics of the foredune to improve its role in sea defence.
Arens, S. M. +3 more
core +2 more sources
مجلة النهرين للعلوم الهندسية, 2017 In this work , experimental investigation has been done for free-convection heat transfer from rectangular fins array on a heated horizontal base plate to surrounding air in the steady-state flow condition with rectangular notch portion effects.
Saad Najeeb Shehab
doaj
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Current Biology, 1999 What are they? The Notch proteins are transmembrane receptors that regulate differentiation in all types of tissues and organisms. The Notch family includes lin12 and glp1 from Caenorhabditis elegans, and mammalian Notch1 to Notch4. All the Notch proteins have extracellular EGF-like repeats for ligand binding, and intracellular RAM23 and ankyrin ...
openaire +2 more sources
On the Stress Concentration in Multiple Notches
, 1962 The two-dimensional photoelastic investigation has been made on the effect of plate width, pitch, and depth of notch on the stress-concentration factor in a finite plate, which is for the single and multiple notches of any depth, under pure bending. Thus
Kunio Nishioka, Nobuyoshi Hisamitsu
core +1 more source
The influence of Notches on Domain Dynamics in Ferroelectric Nanowires [PDF]
, 2010 The extent to which notches inhibit axial switching of polarization in ferroelectric nanowires was investigated by monitoring the switching behavior of single crystal BaTiO(3) wires before and after patterning triangular notches along their lengths ...
S. C. Haire +13 more
core +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source