Results 31 to 40 of about 1,450 (257)

The Strategy of Ontological Negativity in Meister Eckhart’s Metaphysics and in Philosophical Traditions of India

Religions, 2018
In this article, the authors investigate ontological strategies in Meister Eckhart’s metaphysics, which remounts Neoplatonism and the Corpus Areopagiticum, and in two schools of Indian philosophical tradition, the Advaita Vedanta and Early Buddhism.
Tatyana Lifintseva, Dmitry Tourko
doaj   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

The category of Nothingness as a factor in the aesthetics and poetics of modernist literature

Семиотические исследования
The article defines the specifics of the influence of ideas about Nothingness on the artistic philosophy and aesthetics of modernism. It is stated that the feeling of the "liminal" time created an ambiguous perception of the world: the mystical fear of ...
Roman G. Zhitko
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Nothingness at the Crossroads of Minor Canons

Asian Studies
It is a mainstream assumption that Asian thinkers, and Chinese in particular, have devoted much of their speculative energies to investigating emptiness and nothingness, whereas these philosophical concepts would have been neglected (if not abhorred) in
Selusi Ambrogio
doaj   +1 more source

Run away illness where a rooster does not sing: No-life and nothingness in our folk fables [PDF]

Glasnik Etnografskog Instituta SANU, 2008
In fables, verbal messages meant for curing, illness is never sent into underworld, nor is it wished for its death. After the analysis, the author concludes the reason for this attitude is in the understanding of the underworld: according to this view ...
Đapović Lasta
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Sitting at the Kantian Table of Nothingness

JoLMA
This article appeals to the table of nothingness (Nichts) occurring within Kant’s Critique of Pure Reason [1781; 1787] (1998) to assess three recent accounts of nothingness – (Priest 2014), (Costantini 2020), and (Casati & Fujikawa 2019) - under ...
Simionato, Marco
doaj   +1 more source

Artistically Man Dwells: Advenant as an Actor in the Philosophy of Claude Romano

Profil, 2022
The study interprets the event hermeneutics of the French phenomenologist Claude Romano, which he postulated in the publications Event and World, Event and Time and There Is, through the prism of artistic experience.
Marcel Šedo
doaj   +1 more source