Results 171 to 180 of about 210,426 (300)

Editorial [PDF]

, 2004
Toft, Anne Elisabeth
core  

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Gestion optimisée des intrants pour une réponse efficace en contexte de pandémie au Cameroun. [PDF]

J Public Health Afr
Fokam J, Abega Abega CA, Jagni Semengue EN, Abba A, Takou D, Beloumou GA, Djupsa Ndjeyep SC, Nka AD, Anguechia Gouissi DH, Ngwese Tambe DA, Collins C, Christelle Ka'e A, Tommo Tchouaket MC, Nayang Mundo RA, Kengni Ngueko AM, Etame NK, F Moko LG, Molimbou E, Togna Pabo WL, Patricia Tueguem P, Fainguem N, Mba LF, Yatchou LG, Ibnou N, Bienvenu Onana T, Boum Y, Etoundi Mballa AG, Ndjolo A.   +27 more
europepmc   +1 more source

Model per a l'obertura de nous mercats de materials d'enginyeria en països àrabs

, 2016
El present Treball de Final de Grau, que porta com a títol Model per a l’obertura de nous mercats de materials d’enginyeria en països àrabs, pretén presentar un arquetip òptim d’entrada a alguns dels mercats àrabs més significatius del món.
openaire   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Engagement in advance care planning: effect of playing the card game Anticip'action in a community setting. [PDF]

BMC Public Health
Molnar D, Metoukam Bauquis V, Clavien C.
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Investigating the threat of AI to undergraduate medical school admissions: a study of its potential impact on the rating of applicant essays. [PDF]

Can Med Educ J
Choi J, Zhao J, Ngo TA, Grierson L.
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source