Results 51 to 60 of about 122,049 (241)

Whole-Genome Survey and Microsatellite Marker Detection of Antarctic Crocodile Icefish, Chionobathyscus dewitti

open access: yesAnimals, 2022
The crocodile icefish, Chionobathyscus dewitti, belonging to the family Channichthyidae, is an endemic species of the Southern Ocean. The study of its biological features and genetics is challenging as the fish inhabits the deep sea around Antarctic ...
Jinmu Kim   +7 more
doaj   +1 more source

The complete chloroplast genome of Meconopsis pinnatifolia and Meconopsis paniculata

open access: yes, 2023
Two species, Meconopsis pinnatifolia and Meconopsis paniculate, were newly collected from Qinghai-Tibet plateau (QTP), China at altitudes of 3,944m and 3,632m respectively in 2022.
Shuqi Zhao (16946760)
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

Analyses of DNA-protein interaction for four R2R3-MYB family transcription factors linked to wood formation in Eucalyptus using DAP-seq

open access: yes, 2023
DAP-seq was used to identify transcription factor binding sites for EgrMYB1 (Eucgr.G01774), EgrMYB2 (Eucgr.G03385), EgrMYB122 (Eucgr.J01601) and EgrMYB135 (Eucgr.K02297) transcription factors. Sequencing was carried out on an Illumina NovaSeq 6000 (PE150)
Lazarus Takawira (17547396)
core   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

open access: yesMolecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

The complete chloroplast genome of Pterobryopsis orientalis (Pterobryaceae, Hypnales) and its phylogenetic implications

open access: yesMitochondrial DNA. Part B. Resources, 2022
Pterobryopsis orientalis (Müll. Hal.) M. Fleisch. 1917, a subtropical moss from the family Pterobryaceae, is native to the western Himalaya. In this study, the complete chloroplast genome of P.
Wei Han   +4 more
doaj   +1 more source

Rhizobium acaciae sp. nov., a new nitrogen-fixing symbiovar isolated from root nodules of Acacia saligna in Tunisia

open access: yes, 2023
International audienceThe draft genome sequences of 1AS11 T , 1AS12 and 1AS13 were deposited under the accession numbers JAPCZM000000000, JAPCZN000000000 and JAPCZO000000000, respectively.The Illumina NovaSeq 6000 raw reads are deposited in the Sequence ...
Ellouze, Walid   +29 more
core   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

open access: yesMolecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara   +10 more
wiley   +1 more source

Transcriptome dataset to investigate the effect of deep seawater on the gene expression and functional compounds of leaves of Ligularia stenocephalaNCBI.

open access: yesData in Brief
Seawater is often applied to improve crop quality by supplying minerals to the crop. Due to high salt concentration of seawater, one of key factors for successful utilization of seawater in agriculture would be optimal dilution ratios, which can be ...
Dewi Komang Anggita   +3 more
doaj   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

open access: yesFEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain   +11 more
wiley   +1 more source

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