Results 151 to 160 of about 1,890,470 (317)

Screening of antibacterial compounds with novel structure from the FDA approved drugs using machine learning methods. [PDF]

Aging (Albany NY), 2022
Li WX, Tong X, Yang PP, Zheng Y, Liang JH, Li GH, Liu D, Guan DG, Dai SX.   +8 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Identification of a novel class of mammalian phosphoinositol-specific phospholipase C enzymes.

, 2010
Phosphoinositol (PhoIns)-specific phospholipase C enzymes (PLCs) are central to the inositol lipid signaling pathways and contribute to intracellular Ca2+ release and protein kinase C activation. Five distinct classes of PhoIns-specific PLCs are known to
Farquharson, C, Lester, D, Roberts, SJ, Stewart, AJ, Mukherjee, J   +4 more
core  

Imidazolinium chloride salts bearing wingtip groups: Synthesis, molecular docking and metabolic enzymes inhibition

, 2019
A series of symmetrical imidazolinium chloride salts bearing secondary N-alkyl substituents were synthesized in good yield by the reaction of N,N'-dialkylethane-1,2-diamines and HC(OEt)(3) in the presence of NH4Cl.
Karaman, Muhammet, Kaya, Ruya, Özdemir, İsmail, Taslimi, Parham, Gülçin, İlhami, Isik, Yilmaz, Işık, Yılmaz, Yiğit, Beyhan, Yiğit, Murat   +8 more
core   +1 more source

Novel structure in the nuclei of honey bee brain neurons revealed by immunostaining. [PDF]

Sci Rep, 2021
Hurd PJ, Grübel K, Wojciechowski M, Maleszka R, Rössler W.   +4 more
europepmc   +1 more source

Congenital factor V deficiency in a pediatric patient causing mild hemorrhage

Hematology
Background and Aims This study aimed to elucidate the phenotype and genotype of a patient (9-year-old) with coagulation factor V (FV) deficiency to enhance our understanding of this specific disorder.Methods FV activity and antigen level were evaluated ...
Haiyue Zhang, Jun Wu
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Fabrication of novel double-hetero-epitaxial SOT structure Si/gamma-Al2O3/Si

, 2003
In this paper, we report the fabrication of Si-based double-hetero-epitaxial silicon on insulator (SOI) structure Si/gamma-Al2O3/Si. Firstly, single crystalline gamma-Al2O3(100) insulator films were grown epitaxially on Si(100) using the sources of TMA ...
Wang QY, Lin LY, Liu ZL, Yu YH, Tan LW,Chinese Acad Sci,Inst Semicond,Novel Semicond Mat Lab,Ctr Mat Sci,Beijing 100083,Peoples R China., Tan LW, Wang J   +6 more
core  

A novel structure-based approach for identification of vertebrate susceptibility to SARS-CoV-2: Implications for future surveillance programmes. [PDF]

Environ Res, 2022
Kaushik R, Kumar N, Zhang KYJ, Srivastava P, Bhatia S, Malik YS.   +5 more
europepmc   +1 more source

Surface modification strategies for silicon based anodes coated with polymer-derived carbon source

Review of Materials Research
By forming alloys with Li ions, silicon (Si) can possess an energy capacity ten times that of graphite anodes, making it a promising candidate for the next generation anode materials for lithium-ion batteries.
Jie Gao, Guodong Yang, Wanwen Huang, Zi-Chen Lin, Lei Miao, Yuanyuan Jiang, Jianhua Zhou, Jun-Liang Chen, Haiqing Qin, Feng Dang   +9 more
doaj   +1 more source