Results 141 to 150 of about 1,890,470 (317)

Structure-Based Design of a Novel Series of Nonpeptide Ligands That Bind to the pp60^src SH2 Domain

, 2016
The SH2 domain of pp60c-src (Src), a nonreceptor tyrosine kinase, facilitates signal transduction in a number of cell types through binding to cognate phosphorylated protein sequences.
Kimberly S. Para (3001803), James S. Marks (3001806), James H. Fergus (3001812), Christine Humblet (2289181), J. Ronald Rubin (3001809), Tomi K. Sawyer (2356600), Elizabeth A. Lunney (2531989)   +6 more
core   +1 more source

Retracted: A Novel Structure of Blockchain Applied in Vaccine Quality Control: Double-Chain Structured Blockchain System for Vaccine Anticounterfeiting and Traceability. [PDF]

J Healthc Eng, 2023
Healthcare Engineering JO.
europepmc   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

The crystal structure of the platelet activator aggretin reveals a novel (alphabeta)2 dimeric structure

, 2008
Aggretin is a C-type lectin purified from Calloselasma rhodostoma snake venom. It is a potent activator of platelets, resulting in a collagen-like response by binding and clustering platelet receptor CLEC-2.
Papagrigoriou, Evangelos, Pandey, Amit V, Hooley, Elizabeth, Navdaev, Alexei, Clemetson, Kenneth J, Emsley, Jonas, Clemetson, Jeannine M   +6 more
core   +1 more source

Immunomodulatory Activity In Vitro and In Vivo of a Sulfated Polysaccharide with Novel Structure from the Green Alga Ulvaconglobata Kjellman. [PDF]

Mar Drugs, 2022
Cao S, Yang Y, Liu S, Shao Z, Chu X, Mao W.   +5 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Mechanisms of Secondary Structure Breakers in Soluble Proteins [PDF]

, 2005
Breaking signals of secondary structure put strong limitations on the tertiary structures of proteins. In addition to proline and glycine clusters, which are well-known secondary structure breakers, clusters of amphiphilic residues were found to be a ...
Mitaku, Shigeki, Imai, Kenichiro
core  

Formulation of the novel structure curcumin derivative-loaded solid lipid nanoparticles: synthesis, optimization, characterization and anti-tumor activity screening in vitro. [PDF]

Drug Deliv, 2022
Li K, Pi C, Wen J, He Y, Yuan J, Shen H, Zhao W, Zeng M, Song X, Lee RJ, Wei Y, Zhao L.   +11 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Development of Novel Solar Cell Design based on Current Energy Converted from Phonon Energy by Controlling the Phonon Transport

The paper mainly focuses on the Development of Novel Solar Cell Design based on Current Energy Converted from Phonon Energy by Controlling the Phonon Transport. The research challenges in this study are: to find a means of the control of phonon transport
Soe, Khaing Thandar, Pradhan, Devasis, Khin, Ei Ei, Win, Lei Lei Yin, Hla Myo Tun, Tin Swe, Hsu Myat   +5 more
core   +1 more source