Results 131 to 140 of about 1,890,470 (317)

Design, Synthesis, Computational and Biological Evaluation of Novel Structure Fragments Based on Lithocholic Acid (LCA). [PDF]

Molecules, 2023
Peng J, Fan M, Huang KX, Huang LA, Wang Y, Yin R, Zhao H, Xu S, Li H, Agua A, Xie J, Horne DA, Kandeel F, Huang W, Li J.   +14 more
europepmc   +1 more source

Synthesis and crystal structures of five fluorinated diphenidine derivatives

Acta Crystallographica Section E: Crystallographic Communications
Diphenidine (1a), a dissociative anaesthetic, was first reported in 2013. Since then, a number of derivatives e.g. 2-methoxphenidine (1b) have been produced by clandestine laboratories and sold as research chemicals. Fluorinated diphenidines, namely, [1-(
Ryan E. Mewis, Matthew C. Hulme, Jack Marron, Stuart K. Langley, Oliver B. Sutcliffe, Sophie L. Benjamin   +5 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Numerical study of granular flow in a slit funnel with a novel structure to avoid particle clogging. [PDF]

PLoS One, 2023
Peng Y, Zhang S, Wan J, Yang Y, Tao K, Ma L, Yang G, Yang L, Wang M.   +8 more
europepmc   +1 more source

Grammar Cases in Novels “Kita Pergi Hari Ini” Based onCharles J. Fillmore's Perspective

Jurnal Sastra Indonesia
The dialogue and narration in the novel Kita Pergi Hari Ini by Ziggy Zezsyazeoviennazabrizkie are interesting to study in more depth. The researcher uses case grammar based on the perspective of Charles J.
Nabila Nur Khonsa, Abdul Muntaqim Al Anshory, Aldrian, Mellinda Raswari Jambak, Alam An Shori   +4 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Using a novel structure/function approach to select diverse swine major histocompatibility complex 1 alleles to predict epitopes for vaccine development. [PDF]

Bioinformatics, 2023
Khatooni Z, Teymourian N, Wilson HL.
europepmc   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

A pseudo-merohedrally twinned rare-earth sulfate: K6[Ce(HSO4)2(SO4)4]·H2O, a novel structure type

, 2007
A novel structure type of an acidic rare-earth sulfate, hexapotassium cerium dihydrogensulfate tetrasulfate monohydrate, is reported. The crystal is twinned, mimicking tetragonal symmetry.
Casari, Barbara M., Langer, Vratislav,
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