Results 111 to 120 of about 1,890,470 (317)

Novel Conformation of an RNA Structural Switch

Biochemistry, 2012
The RNA duplex, (5'GACGAGUGUCA)(2), has two conformations in equilibrium. The nuclear magnetic resonance solution structure reveals that the major conformation of the loop, 5'GAGU/3'UGAG, is novel and contains two unusual Watson-Crick/Hoogsteen GG pairs with G residues in the syn conformation, two A residues stacked on each other in the center of the ...
Kennedy, Scott D., Kierzek, Ryszard, Turner, Douglas H.   +2 more
openaire   +2 more sources

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

"REMEMBER MY LAST THREE WORDS": TO THE QUESTION OF STRUCTURE OF TURGENEV’S NOVEL FINALS

, 2018
The article deals with the distinctive feature of Turgenev’s novel finals, in which the writer always highlights the «final point» that is significant in the artistic, structural and semantic sense.

core   +1 more source

Avis sur la monographie « Le concept de vertu pratique dans les romans de Mme de Genlis », auteur Ecaterina Foghel, manuscrit, 134 p.

Limbaj si Context
The review focuses on a unique monograph, which studies a very interesting and little-researched topic in the linguistics. The review thoroughly analyzes the structure of the monograph, emphasizes its originality, theoretical and applicative value.
Ion Guţu
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Crystal structure of recombinant human interleukin-22

, 2015
Interleukin-22 (IL-10-related T cell-derived inducible factor/IL-TIF/IL-22) is a novel cytokine belonging to the IL-10 family. Recombinant human IL-22 (hIL-22) was found to activate the signal transducers and activators of transcription factors I and 3 ...
Colau, D, Dumoutier, L, Nagem, RAP, Polikarpov, I, Renauld, JC, Ogata, C   +5 more
core   +1 more source

FLORA: a novel method to predict protein function from structure in diverse superfamilies [PDF]

, 2009
Predicting protein function from structure remains an active area of interest, particularly for the structural genomics initiatives where a substantial number of structures are initially solved with little or no functional characterisation.
Dallman Timothy J., Nussinov, R., Oliver C. Redfern, Christine A. Orengo, Sillitoe, I., Dessailly Benoît H., Orengo, C.A., Benoît H Dessailly, Redfern, OC, Timothy J. Dallman, Oliver C Redfern, Benoît H. Dessailly, Dallman, TJ, Dessailly, B.H., Orengo Christine A., Ian Sillitoe, Timothy J Dallman, Sillitoe, I, Redfern Oliver C., Christine A Orengo, Dallman, T.J., Sillitoe Ian, Dessailly, BH, Redfern, O.C., Orengo, CA   +24 more
core   +1 more source

Magnetocaloric Effect in 3D Gd(III)-Oxalate Coordination Framework

Nanomaterials
Cryogenic magnetic refrigerants based on the magnetocaloric effect (MCE) hold significant potential as substitutes for the expensive and scarce He-3. Gd(III)-based complexes are considered excellent candidates for low-temperature magnetic refrigerants ...
Fang-Wen Lv, Mei-Xin Hong, Xue-Ting Wang, Haiquan Tian, Chun-Chang Wang, Xiu-Ying Zheng   +5 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

A novel cGUUAg tetraloop structure with a conserved yYNMGg-type backbone conformation from cloverleaf 1 of bovine enterovirus 1 RNA

, 2006
The 5'-terminal cloverleaf (CL)-like RNA structures are essential for the initiation of positive- and negative-strand RNA synthesis of entero- and rhinoviruses.
Görlach, Matthias, Zacharias, Martin, Häfner, Sabine, Ramachandran, Ramadurai, Ihle, Yvonne, Ohlenschläger, Oliver, Zell, Roland, Seitz, Simone, Duchardt-Ferner, Elke   +8 more
core   +1 more source