Results 81 to 90 of about 1,890,470 (317)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Crystal structure of nitrile hydratase reveals a novel iron centre in a novel fold

, 1997
Background: Nitrile hydratases are unusual metalloenzymes that catalyze the hydration of nitriles to their corresponding amides. They are used as biocatalysts in acrylamide production, one of the few commercial scale bioprocesses, as well as in ...
Cummings, J, Nelson, M, Huang, Weijun, Lindqvist, Ylva, Lindqvist, Y,, Schneider, Gunter, Schneider, G, Jia, Jia, Cummings, John, Huang, WJ, Nelson, Mark, Jia, J   +11 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

A Novel Embedded Torque Sensor of Body Structure Designed and Optimized

, 2014
Aiming at a new embedded torque sensor, based on the principle of measuring the relative displacement from inner and outer rings to know the transfer torque size, we designed a novel body structure.
Tian T(田恬), Wu JF(武加峰), Liu YW(刘玉旺), LEI,Ying-Bo, CHEN,Chen   +4 more
core  

Effect of iron acetylacetonate on the crosslink structure, thermal and flammability properties of novel aromatic diamine-based benzoxazines containing cyano group

, 2015
Iron acetylacetonate (Fe(AcAc)3) was chosen as the catalyst for a novel aromatic diamine-based benzoxazine, containing cyano group (BAPBACP). Its effect on the curing process, thermal and flammability properties of BAPBACP were investigated.
Cheng, Jie, Fang, Zhengping, Yan, Hongqiang, Wang, Huaqing, Wang, Hao   +4 more
core   +1 more source

Enhancing implant surfaces: mechanical stability and cytocompatibility of DNase I coatings deposited by alternating current electrophoretic deposition

Frontiers in Bioengineering and Biotechnology
Deoxyribonuclease I (DNase I) is an enzyme that hydrolyzes the phosphodiester bonds in the DNA backbone, enabling efficient DNA degradation. This activity is particularly relevant for degrading extracellular DNA (eDNA), a key structural component of the ...
Merve Kübra Aktan, Naiera Zayed, Naiera Zayed, Aydan Yadigarli, Manuela Sonja Killian, Rob Lavigne, Wim Teughels, Annabel Braem   +7 more
doaj   +1 more source

The structure of a LAIR1-containing human antibody reveals a novel mechanism of antigen recognition

eLife, 2017
Antibodies are critical components of the human adaptive immune system, providing versatile scaffolds to display diverse antigen-binding surfaces. Nevertheless, most antibodies have similar architectures, with the variable immunoglobulin domains of the ...
Fu-Lien Hsieh, Matthew K Higgins
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Development of an Insulin‐Permeable Hydrogel Membrane Based on Photocrosslinkable Poly(2‐Alkyl‐2‐Oxazoline)s

Macromolecular Materials and Engineering
This study presents the development of insulin‐permeable hydrogel‐based composite membranes from photocrosslinkable poly(2‐alkyl‐2‐oxazoline)s. The membrane design addresses the challenge of maintaining protein structural integrity during delivery ...
Aliia Ibragimova, Daria V. Berdnikova, Maren Kipping, Swathi N. V. Raghu, Manuela S. Killian, Ulrich Jonas   +5 more
doaj   +1 more source