Results 201 to 210 of about 23,054 (234)
NOX4 Regulates Autophagy During Energy Deprivation [PDF]
Autophagy, 2014 NADPH oxidase is a cellular enzyme devoted to the production of reactive oxygen species (ROS). NOX4 and NOX2 are the main isoforms of NADPH oxidase in the cardiovascular system. In our recent study, we demonstrated that NOX4, but not NOX2, is a critical mediator of the cardiomyocyte adaptive response to energy stress.
Sebastiano Sciarretta +2 more
exaly +4 more sources
LPS-Induced Acute Kidney Injury Is Mediated by Nox4-SH3YL1
Cell Reports, 2020 Cytosolic proteins are required for regulation of NADPH (nicotinamide adenine dinucleotide phosphate) oxidase (Nox) isozymes. Here we show that Src homology 3 (SH3) domain-containing YSC84-like 1 (SH3YL1), as a Nox4 cytosolic regulator, mediates ...
Jin Joo Cha +2 more
exaly +2 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
The role of NOX4 in pulmonary diseases
Journal of Cellular Physiology, 2020Abstract Nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4) is a subtype of the NOX family, which is mainly expressed in the pulmonary vasculature and pulmonary endothelial cells in the respiratory system. NOX4 has unique characteristics, and is a constitutively active enzyme that primarily produces hydrogen peroxide.
Zi‐Ming Li +6 more
openaire +2 more sources
Expression of Nox4 in osteoclasts
Journal of Cellular Biochemistry, 2004AbstractA new superoxide‐generating enzyme, NADPH oxidase 4 (Nox4), contributes to osteoclastic superoxide production. In this study, we demonstrated that Nox4 is expressed at a higher level in osteoclasts than that in precursor cells. This result suggested that Nox4 is upregulated during the differentiation and development of osteoclasts ...
Su, Yang +3 more
openaire +2 more sources
Nox4 in renal diseases: An update
Free Radical Biology and Medicine, 2018Reactive oxygen species derived from NADPH oxidase contribute to a wide variety of renal diseases. Nox4, the major NADPH isoform in kidney, produces mainly H2O2 that regulates physiological functions. Nox4 contributes to redox processes involved in diabetic nephropathy, acute kidney injury, obstructive nephropathy, hypertensive nephropathy, renal cell ...
Qin, Yang +13 more
openaire +2 more sources
Biochimie, 2011
Nox4, a member of Nox family of NADPH oxidase expressed in nonphagocytic cells, is a major source of reactive oxygen species in many cell types. But understanding of the role of Nox4 in the production of ROS and of regulation mechanism of oxidase activity is largely unknown. This study reports for the first time the generation and characterization of 5
Leilei, Zhang +9 more
openaire +2 more sources
Nox4, a member of Nox family of NADPH oxidase expressed in nonphagocytic cells, is a major source of reactive oxygen species in many cell types. But understanding of the role of Nox4 in the production of ROS and of regulation mechanism of oxidase activity is largely unknown. This study reports for the first time the generation and characterization of 5
Leilei, Zhang +9 more
openaire +2 more sources
NADPH oxidase Nox4 in osteoporosis
Free Radical Biology and Medicine, 2018Bone is a tissue with an enormous level of constant remodeling. Osteoblast form and osteoclasts degrade bone. Both represent highly specialized cells that form from precursors and have to be replaced on a regular basis. Reactive oxygen species are involved in differentiation of many cell types. A major source of ROS is the family of NADPH oxidases. The
openaire +1 more source
Nox4, Poldip2 and vascular function
Free Radical Biology and Medicine, 2018NADPH oxidases (Nox) are expressed in all layers of the vessel wall and are integral to vascular physiology. Of particular interest is Nox4, which regulates vascular smooth muscle differentiation and vessel relaxation, but also has pathophysiological roles.
openaire +1 more source