NADPH Oxidase 4: A Potential Therapeutic Target of Malignancy [PDF]
Frontiers in Cell and Developmental Biology, 2022 Reactive oxygen species (ROS) play a crucial role in the regulation of tumor occurrence and development. As a main source of ROS, NADPH oxidases are key enzymes that mediate electron transport within intracellular membranes.
Shulei Gong, Shiyang Wang, Mingrui Shao
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NADPH oxidase 4 is protective and not fibrogenic in intestinal inflammation [PDF]
Redox Biology, 2020 Dysregulated redox signaling and oxidative injury are associated with inflammatory processes and fibrosis. H2O2 generation by NOX4 has been suggested as a key driver in the development of fibrosis and a small molecule drug is under evaluation in clinical
Emily Stenke +9 more
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NADPH oxidase 4 deficiency attenuates experimental osteoarthritis in mice [PDF]
RMD Open, 2023 Objective Low-grade inflammation plays a pivotal role in osteoarthritis (OA) through exposure to reactive oxygen species (ROS). In chondrocytes, NADPH oxidase 4 (NOX4) is one of the major ROS producers.
Felix Renaudin +9 more
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NADPH oxidase 4 (NOX4) as a biomarker and therapeutic target in neurodegenerative diseases [PDF]
Neural Regeneration ResearchDiseases like Alzheimer's and Parkinson's diseases are defined by inflammation and the damage neurons undergo due to oxidative stress. A primary reactive oxygen species contributor in the central nervous system, NADPH oxidase 4, is viewed as a potential ...
Napissara Boonpraman, Sun Shin Yi
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NADPH oxidase 4 (Nox4) deletion accelerates liver regeneration in mice [PDF]
Redox Biology, 2021 Liver is a unique organ in displaying a reparative and regenerative response after acute/chronic damage or partial hepatectomy, when all the cell types must proliferate to re-establish the liver mass.
M. Herranz-Itúrbide +11 more
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Acid sphingomyelinase promotes diabetic cardiomyopathy via NADPH oxidase 4 mediated apoptosis [PDF]
Cardiovascular Diabetology, 2023 Background Increased acid sphingomyelinase (ASMase) activity is associated with insulin resistance and cardiac dysfunction. However, the effects of ASMase on diabetic cardiomyopathy (DCM) and the molecular mechanism(s) underlying remain to be elucidated.
Ruijiao Liu +6 more
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NADPH oxidase 4 is dispensable for skin myofibroblast differentiation and wound healing [PDF]
Redox Biology, 2023 Differentiation of fibroblasts to myofibroblasts is governed by the transforming growth factor beta (TGF-β) through a mechanism involving redox signaling and generation of reactive oxygen species (ROS).
Aleksandra Malgorzata Siedlar +11 more
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NADPH oxidase 4 signaling in a ventilator-induced lung injury mouse model [PDF]
Respiratory Research, 2022 Background For patients with acute respiratory distress syndrome, a ventilator is essential to supply oxygen to tissues, but it may also cause lung damage.
Sang Hoon Lee +6 more
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Sestrin2 Attenuates Cellular Senescence by Inhibiting NADPH Oxidase 4 Expression [PDF]
Annals of Geriatric Medicine and Research, 2020 Background Sestrin2 (Sesn2) is involved in the maintenance of metabolic homeostasis and aging via modulation of the 5' AMP-activated protein kinase-mammalian target of rapamycin (AMPK-mTOR) pathway.
Chae Young Hwang +5 more
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NADPH oxidase 4 inhibition is a complementary therapeutic strategy for spinal muscular atrophy [PDF]
Frontiers in Cellular Neuroscience, 2023 IntroductionSpinal muscular atrophy (SMA) is a fatal neurodegenerative disorder, characterized by motor neuron (MN) degeneration and severe muscular atrophy and caused by Survival of Motor Neuron (SMN) depletion.
Mirella El Khoury +13 more
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