Results 41 to 50 of about 85,856,906 (279)

Therapeutic potential of NADPH oxidase 1/4 inhibitors [PDF]

British Journal of Pharmacology, 2016
The NADPH oxidase (NOX) family of enzymes produces ROS as their sole function and is becoming recognized as key modulators of signal transduction pathways with a physiological role under acute stress and a pathological role after excessive activation under chronic stress.
Teixeira, G, Szyndralewiez, C, Molango, S, Carnesecchi, S, Heitz, F, Wiesel, P, Wood, J M   +6 more
openaire   +3 more sources

Neutrophil antimicrobial defense against Staphylococcus aureus. contribution of cathelicidin and the NADPH oxidase [PDF]

, 2009
Neutrophils are among the most important components of the innate immune response, which provides the first line of host defense. The antimicrobial potential of neutrophils has been traditionally divided into either non-oxidative or oxidative ...
Jann, Naja
core   +1 more source

Rosmarinic acid protects against hypertensive nephropathy by inhibiting NADPH oxidase/ROS/NLRP3 inflammasome pathway

Di-san junyi daxue xuebao, 2021
Objective To investigate the protective effect of rosmarinic acid (RA) on hypertensive nephropathy in mice and its underlying mechanism. Methods Thirty male C57BL/6 mice (6~8 weeks) were randomly divided into 3 groups: control group, AngⅡ group ...
CHEN Ruidan, ZHANG Yan, YANG Peili, LI Fangtang, CHEN Ken, YANG Yongjian   +5 more
doaj   +1 more source

NADPH Oxidase 4 Induces Cardiac Arrhythmic Phenotype in Zebrafish [PDF]

Journal of Biological Chemistry, 2014
Oxidative stress has been implicated in cardiac arrhythmia, although a causal relationship remains undefined. We have recently demonstrated a marked up-regulation of NADPH oxidase isoform 4 (NOX4) in patients with atrial fibrillation, which is accompanied by overproduction of reactive oxygen species (ROS).
Zhang, Yixuan, Shimizu, Hirohito, Siu, Kin Lung, Mahajan, Aman, Chen, Jau-Nian, Cai, Hua   +5 more
openaire   +4 more sources

NADPH oxidase (NOX) in the heart : the interplay of NOX-derived ROS in β1-integrin-induced survival signalling [PDF]

, 2011
Moderate levels of reactive oxygen species (ROS) act as mediators in cellular signalling processes. An important source of cardiac ROS is the highly expressed NADPH oxidase (NOX) family isoform NOX2. However, little is known about whether NOX-derived ROS
Rosc-Schlüter, Berit Ines
core   +1 more source

Flagellin-induced NADPH oxidase 4 activation is involved in atherosclerosis [PDF]

Scientific Reports, 2016
AbstractIt is widely accepted that bacterial infection-mediated inflammation facilitates development of atherosclerosis by activating toll-like receptor (TLR) signaling system. We reasoned that NADPH oxidases (Nox), required for TLR-mediated inflammatory response, are involved in atherogenesis.
Kim, Jinoh, Seo, Misun, Kim, Su Kyung, Bae, Yun Soo   +3 more
openaire   +3 more sources

A case-control study of rheumatoid arthritis identifies an associated single nucleotide polymorphism in the NCF4 gene, supporting a role for the NADPH-oxidase complex in autoimmunity [PDF]

, 2007
Rheumatoid arthritis (RA) is a chronic inflammatory disease with a heritability of 60%. Genetic contributions to RA are made by multiple genes, but only a few gene associations have yet been confirmed.
Klareskog, Lars, Lars Klareskog, Rikard Holmdahl, Kallberg, H, Padyukov, L, Lars Alfredsson, Harald Burkhardt, Padyukov, Leonid, Olsson, Lina, Holmdahl, Rikard, Lina M Olsson, Burkhardt, H, Anna-Karin Lindqvist, Leonid Padyukov, Lindqvist, Anna-Karin,, Burkhardt, Harald, Klareskog, L, Lindqvist, Anna-Karin, Olsson, Lina M., Henrik Källberg, Olsson, Lina,, Källberg, Henrik, Alfredsson, Lars, Alfredsson, L, Lund University., Holmdahl, Rikard,, Alfredsson, L,, Klareskog, L,, Lindqvist, A-K, Olsson, LM, Holmdahl, R,, Padyukov, L,   +31 more
core   +1 more source

Alkalinity of Neutrophil Phagocytic Vacuoles Is Modulated by HVCN1 and Has Consequences for Myeloperoxidase Activity. [PDF]

, 2015
The NADPH oxidase of neutrophils, essential for innate immunity, passes electrons across the phagocytic membrane to form superoxide in the phagocytic vacuole.
Adam P Levine, Michael R Duchen, Peter R. Rich, Anthony W. Segal, Adam P. Levine, de Villiers, S, Anthony W Segal, Simon de Villiers (725764), Peter R. Rich (725765), Michael R. Duchen (49273), Peter R Rich, Levine, AP, Duchen, MR, Simon de Villiers, Michael R. Duchen, Rich, PR, Adam P. Levine (473969), Anthony W. Segal (251124), Segal, AW, Rich Peter R., Segal Anthony W., Duchen Michael R., de Villiers Simon, Levine Adam P.   +23 more
core   +1 more source

Renal denervation attenuates hypertension and renal dysfunction in a model of cardiovascular and renal disease, which is associated with reduced NADPH and xanthine oxidase activity

Redox Biology, 2017
Oxidative stress is considered a central pathophysiological event in cardiovascular disease, including hypertension. Early age reduction in renal mass is associated with hypertension and oxidative stress in later life, which is aggravated by increased ...
Maria Peleli, Peter Flacker, Zhengbing Zhuge, Cristina Gomez, Craig E. Wheelock, A. Erik G. Persson, Mattias Carlstrom   +6 more
doaj   +1 more source

Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis

Hepatology, EarlyView., 2022
EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu, Xiude Fan, Megan R. McMullen, Tatsunori Miyata, Adam Kim, Vai Pathak, Jianguo Wu, Le Z. Day, Josiah E. Hardesty, Nicole Welch, Jaividhya Dasarathy, Daniela S. Allende, Arthur J. McCullough, Jon M. Jacobs, Daniel M. Rotroff, Srinivasan Dasarathy, Laura E. Nagy   +16 more
wiley   +1 more source