Circulation Research, 2009 Over the last decade, the NADPH oxidases have been recognized as an important source of reactive oxygen species (ROS) involved in both normal physiologic redox-dependent processes, and in the generation of oxidative stress, with a role in the development of cardiovascular disease.
openaire +2 more sources
Potential role of NADPH-oxidase in early steps of lead-induced oxidative burst in Vicia faba roots [PDF]
, 2008 The mechanism of oxidative burst induced by lead in Vicia faba excised roots was investigated by luminol-dependent chemiluminescence. Results showed that lead triggered a rapid and dose-dependent increase in chemiluminescence production.
Perchet, Geoffrey-Thibault +7 more
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Inhibition of NADPH oxidase activation in oligodendrocytes reduces cytotoxicity following trauma. [PDF]
PLoS ONE, 2013 Spinal cord injury is a debilitating neurological disorder that initiates a cascade of cellular events that result in a period of secondary damage that can last for months after the initial trauma.
Joshua T Johnstone +8 more
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Cross-talk between IRAK-4 and the NADPH oxidase [PDF]
Biochemical Journal, 2007 Exposure of neutrophils to LPS (lipopolysaccharide) triggers their oxidative response. However, the relationship between the signalling downstream of TLR4 (Toll-like receptor 4) after LPS stimulation and the activation of the oxidase remains elusive. Phosphorylation of the cytosolic factor p47phox is essential for activation of the NADPH oxidase.
Sandrine, Pacquelet +6 more
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Siglec-E promotes β2-integrin-dependent NADPH oxidase activation to suppress neutrophil recruitment to the lung [PDF]
, 2014 Siglec-E is a sialic acid-binding Ig-like lectin expressed on murine myeloid cells. It has recently been shown to function as a negative regulator of ß2-integrin-dependent neutrophil recruitment to the lung following exposure to lipopolysaccharide (LPS).
Hegde, Vikas +9 more
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NADPH oxidase deficient mice develop colitis and bacteremia upon infection with normally avirulent, TTSS-1- and TTSS-2-deficient Salmonella Typhimurium. [PDF]
PLoS ONE, 2013 Infections, microbe sampling and occasional leakage of commensal microbiota and their products across the intestinal epithelial cell layer represent a permanent challenge to the intestinal immune system. The production of reactive oxygen species by NADPH
Boas Felmy +9 more
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Molecules, 2012 The present study was undertaken to test the hypothesis that NADPH oxidase-derived reactive oxygen species (ROS) are involved in isoliquiritigenin (ISL)-induced monocytic differentiation in human acute promyelocytic leukemia HL-60 cells.
Qiusheng Zheng +7 more
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Role of Rac1 GTPase in NADPH oxidase activation and cognitive impairment following cerebral ischemia in the rat. [PDF]
PLoS ONE, 2010 Recent work by our laboratory and others has implicated NADPH oxidase as having an important role in reactive oxygen species (ROS) generation and neuronal damage following cerebral ischemia, although the mechanisms controlling NADPH oxidase in the brain ...
Limor Raz +8 more
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Antioxidants, 2021 Allium sativum L., also known as garlic, is a perennial plant widely used as a spice and also considered a medicinal herb since antiquity. The aim of this study was to determine by gas chromatography–mass spectrometry (GC–MS) the chemical profile ...
Oscar Herrera-Calderon +5 more
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Activation of NADPH oxidase by purine and pyrimidine nucleotides involves G proteins and is potentiated by chemotactic peptides [PDF]
, 1989 Human neutrophils and HL-60 leukaemic cells possess an NADPH oxidase which catalyses superoxide (O2-) formation and is activated by the chemotactic peptide, N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMet-Leu-Phe).
Seifert, Roland +2 more
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